A puppy with natural infection, none of 4 puppies examined 18 to 48 hours after experimental infection, and all of 13 puppies examined 3 to 9 days after experimental infection with a canine herpesvirus had lesions of the central nervous system. These constituted a non-suppurative meningoencephalomyelitis, characterized by focal and segmental destruction of gray and white matter and diffuse and focal microgliosis. In general, the gray matter was most severely involved, especially within the brain stem. The histopathologic findings in this disease are comparable to those in other herpetic encephalitides.
References
1.
CarmichaelL. E.FabricantJ.SquireR. A.:
A fatal septicemic disease of infant puppies caused by cytopathogenic organisms with characteristics of mycoplasma.Proc. Soc. exp. Biol. Med.117:
826–833(1964)
2.
CarmichaelL. E.:
Canine herpesvirus: A recently discovered cause of death in young pups.
15th Gaines veterinary Symposium.24–28(1965)
3.
CarmichaelL. E.SquireR. A.KrookL.:
Clinical and pathological features of a fatal viral disease of newborn pups.Amer. J. vet. Res.26:
803–814(1965)
4.
CarmichaelL. E.StrandbergJ. D.BarnesF. D.:
Identification of a cytopathic agent infectious for puppies as a canine herpesvirus.Proc. Soc. exp. Biol. Med.120:
644–650(1965)
5.
CornwellH. J. C.WrightN. G.CampbellR. S. F.RobertsR. J.ReidA.:
Neonatal disease in the dog associated with a herpes-like virus.Vet. Rec.79:
661–662(1966)
6.
DowC.McFarranJ. B.:
The neuropathology of Aujeszky's disease in the pig.Res. Vet. Sci.3:
436–442(1962)
7.
HallW. T. K.SimmonsG. C.FrenchE. L.SnowdonW. A.AsdellM.:
The pathogenesis of encephalitis caused by the infectious bovine rhinotracheitis virus.Austr. vet. J.42:
229–237(1966)
8.
JohnstonL. A. Y.SimmonsG. C.McGavinM.:
A viral meningoencephalitis of calves.Austr. vet. J.38:
207–215(1962)
9.
LeiderW.MagaffinR. L.LennetteE. H.LeonardsL. N. R.:
Herpes simplex virus encephalitis.New Engl. J. Med.273:
341–347(1965)
OlanderH. J.SaundersJ. R.GustafsonD. P.JonesR. K.:
Pathologic findings in swine affected with a virulent strain of Aujeszky's virus.Path. vet.3:
64–82(1966)
12.
PrydieJ.HarrisonM. J.GrahamJ.:
Isolation of a canine herpesvirus.Vet. Rec.79:
660–661(1966)
13.
De RatuldY.WernerG. H.:
Note sur le virus herpetique canin.
Ann. Inst. Pasteur.
(In press)
SmithM. G.LennetteE. H.ReamesH. R.:
Isolation of the virus of herpes simplex and the demonstration of intranuclear inclusions in a case of acute encephalitis.Amer. J. Path.17:
55–68(1941)
16.
SpertzelR. O.HuxsollD. L.McConnellS. J.BinnL. N.YagerR. H.:
Recovery and characterization of a herpes-like virus from dog kidney cell cultures.Proc. Soc. exp. Biol. Med.120:
651–655(1965)
17.
StewartS. E.David-FerreiraJ.LovelaceE.LandowJ.StockN.:
Herpes-like virus isolated from neonatal and fetal dogs.Science148:
1341–1343(1965)
18.
StrandbergJ. D.CarmichaelL. E.:
Electron microscopy of a canine herpesvirus.J. Bact.90:
1790–1792(1965)
19.
ZuelzerW. W.StulbergC. S.:
Herpes simplex as the cause of fulminating visceral disease and hepatitis in infancy.Amer. J. Dis. Child.83:
421–439(1952)
