Abstract
Abstract
German
At necropsy 28 of 29 dogs with cutaneous mastocytoma had internal accumulations of mast cells in various organs. The order of decreasing incidence in these organs was: regional lymph nodes, spleen, liver, bone marrow, kidneys, lungs, and heart. No correlation was obvious between the size of the external lesions and the extent of internal involvement. A good correlation existed between the degree of anaplasia of the initial external tumor and the extent of subsequent internal involvement. Other significant lesions observed in these dogs included a diffuse plasmacytosis and a chronic focal glomerulitis. The distribution of neoplastic mast cells in some dogs inferred a multicentric origin. The possibility of an autoimmune reaction in these dogs is briefly discussed.
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