Thirty-six hundred ninety-eight guinea pigs of the Dunkin-Hartley strain from the breeding colony at Fort Detrick were necropsied. Four females had mesenchymomas of the heart. The tumors were similar histologically and were composed of multiple benign mesenchymal tissues which were amalgamated into a single mass. One tumor was composed of fibrous, angiomatous, adipose, cartilagenous, osscous, hematopoietic, myxomatous, and possibly smooth muscle tissues. Smooth muscle and myxomatous tissues were not found in the other tumors. All were benign and probably originated from the primitive mesenchyme of the heart.
References
1.
AndersonW. A. D.:
Pathology,
5th Ed.,
p. 438
(C. V. Mosby,
St. Louis, Mo.1966)
2.
AthiasM.:
Sarcome du cœur chez un cobaye après injection, dans le cerveau, de methylcholantrene.Compt rend. Soc. Biol.126:
585–587(1937)
3.
BenderL.:
Sarcoma of the heart in a guinea pig.J. Cancer Res.9:
384–387(1925)
4.
HueperW. C.:
Rhabdomyomatosis of the heart in a guinea pig.Amer. J. Path.17:
121–125(1940)
5.
HydeW. R.WhiteJ. E.StoutA. P.:
Mesenchymoma of mesentery.Cancer3:
653–656(1950)
6.
RooneyJ. R.:
Rhabdomyomatosis in the heart of the guinea pig.Cornell Vet.51:
388–394(1961)
7.
RogerJ. B.BlumenthalH. T.:
Studies of guinea pig tumors: I. Report of fourteen spontaneous guinea pig tumors, with a review of the literature.Cancer Res.20:
191–197(1960)
8.
StoutA. P.:
Mesenchymoma, the mixed tumor of mesenchymal derivatives.Ann. Surg.127:
278–290(1948)
9.
WeberG.:
Rhabdomiom multipli del cuore in Cavia cobaya.Arch. Vecchi Anat. Path. Med. Clin. (Florence)13:
1049(1949)
