Lesions of an acute and chronic ileitis of hamsters were studied. A total of 92 animals between 6 and 12 weeks old was examined. Morbidity and mortality rates were 25 to 60% and 90% respectively. The initial lesion was epithelial hyperplasia of the ileal mucosa. Severe inflammatory changes in the ileum and adjacent structures were secondary. No etiologic agent was isolated. The disease was not neoplastic.
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