Experimental inhalation of nitrogen dioxide by cattle resulted in methemoglobinemia, severe dyspnea and death. Pulmonary lesions consisted of hyperemia, edema, hemorrhage, fibrin deposition, hyperplasia of the respiratory epithelium, obliterative bronchiolitis, infarction and emphysema. There was coagulative necrosis of proximal convoluted tubules and skeletal muscles. The occurrence of lesions other than those described for bovine pulmonary adenomatotis lends no support to the idea that nitrogen dioxide is the cause of this disease.
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