The histopathology of Aujeszky's disease associated with severe clinical signs in mature swine was studied in 46 naturally and experimentally infected pigs, 2 dogs, a sheep, and 5 experimentally infected rabbits. The lesions in swine were characteristically severe, non-suppurative, necrotizing panencephalomyelitis, meningitis, and ganglioneuritis. In naturally infected pigs the anterior regions of the CNS were most severely involved. Swine experimentally inoculated intranasally had a similar distribution of lesions while those inoculated intramuscularly had primarily spinal cord involvement. Lesions in the brains of the dogs and sheep were meager and limited to the brains stems. In rabbits no CNS lesions were found. Necrotizing lesions were also seen in lymph nodes of swine and in livers of experimental rabbits.
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