Intranuclear inclusions of glycogen were detected in 4 of 87 canine mast cell tumours. Intracytoplasmatic accumulations of the same material were found in about 1/3 of all our canine and feline mast cell tumours. Obviously, these inclusions are an expression of the abnormal carbohydrate metabolism of the tumour mast cells. Changes in the permeability of the nuclear membrane are probably necessary for the development of intranuclear glycogen inclusions, whereas the intracytoplasmatic ones obviously can arise on the basis of the disturbed cell metabolism itself, without alteration of the nuclear permeability. The inclusions are not directly related to the viral aetiology of the canine mast cell tumours.
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