A study was made of the fine structure of the hepatocytes of 5 sheep affected with mild to severe lantana poisoning of from 1 to 7 days duration. For comparative purposes, observations were also made of the livers of both well fed and starved normal sheep and a CCl4 poisoned sheep 24 hours after dosing. The earliest and most consistent alteration of the fine structure of the hepatocytes in lantana poisoning was a characteristic separation of the interface plasma membranes with extensive formation of microvilli without significant cytoplasmic changes. This lesion is thought to be characteristic of this type of liver injury. In more severely affected livers, bile canalicular changes were accompanied by marked nuclear and cytoplasmic changes in many hepatocytes. These latter changes however, were considered to be mainly secondary and associated with the retention and regurgitation of bile.
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