Anaplastic large cell lymphoma (ALCL) is a high-grade non-Hodgkin's lymphoma recognized by the expression of the CD30 marker and by its morphology. We report an unusual case of ALCL in a 42-year-old woman. For ten years the patient only had pruritic erythematous skin lesions, then a plaque with nodules and ulcers on the right thigh and leg developed, followed by ichthyosis acquisita. The development of ALCL in women and the association of ichthyosis acquisita with this type of lymphoma are uncommon.
EboD., Van HoofA.: Large cell anaplastic lymphoma. Acta Clin. Belg., 47: 170–173, 1992.
6.
HallP.A., D'ArdenneA.J., StansfeldA.G.: Paraffin section immunohistochemistry II. Hodgkin's disease and large cell anaplastic (Ki-1) lymphoma. Histopathology, 13: 161–169, 1988.
7.
KadinM.E.: Primary Ki-1-positive anaplastic large-cell lymphoma: A distinct clinicopathologic entity. Ann. Oncol., 5(suppl. 1): 25–30, 1994.
8.
KaudewitzP., SteinH., DallenbachF., EckertF., BieberK., BurgG., Braun-FalcoO.: Primary and secondary cutaneous Ki-1+ (CD 30+) anaplastic large cell lymphomas. Morphologic, immunohistologic and clinical characteristics. Am. J. Pathol., 135: 359–367, 1989.
9.
LewisH.M., StampG., StewartS., LeonardJ.N.: Cutaneous large cell anaplastic lymphoma. J. Roy. Soc. Med., 86: 230–231, 1993.
10.
OkaK., MatsumotoT.: Ki-1 positive large cell lymphoma with different phenotypes in skin nodules and lymph nodes. Dermatology, 188: 52–56, 1994.
11.
PallesenG.: The diagnostic significance of the CD30 (Ki-1) antigen. Histopathology, 16: 409–413, 1990.
12.
RalfkiaerE., DelsolG., O’ ConnorN.T., BrandtzaegP., BroussetP., VejlsgaardG.L., MasonD.Y.: Malignant lymphomas of true histiocytic origin. A clinical, histological, immunophenotypic and genotypic study. J. Pathol., 160: 9–17, 1990.
13.
SchwabU., SteinH., GerdesJ., LemkeH., KirchnerH., SchaadtM., DiehlV.: Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells. Nature, 299: 65–67, 1982.
14.
SuchiT., LennertK., TuL.Y., KikuchiM., SatoE., StansfeldA.G., FellerA.C.: Histopathology and immunohistochemistry of peripheral T-cell lymphomas: a proposal for their classification. J. Clin. Pathol., 40: 995–1015, 1987.
15.
VirgiliA., CorazzaM., LombardiA.R., AltieriE.: Ittiosi acquisita associata a linfoma anaplastico a grandi cellule Ki-1+. G. Ital. Dermatol. Venereol., 130: 147–150, 1995.
16.
WeinmanV.F., AckermanA.B.: Lymphomatoid papulosis. A critical review and new findings. Am. J. Dermatopathol., 3: 129–163, 1981.
17.
WillemzeR., BeljaardsR.C.: Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders. J. Am. Acad. Dermatol., 28: 973–980, 1993.
