A mucinous cystadenocarcinoma along with remnants of normal pancreatic tissue was discovered in the spleen of a 21-year-old woman. Extensive clinical, radiological, ultrasound and computed tomography investigation revealed that the patient's pancreas and ovaries were unremarkable. We presume an origin from heterotopic pancreatic tissue for this neoplasm and present a review of the literature in this regard.
ButlerJ.J.: Pathology of the spleen in benign and malignant conditions.Histopathology, 7: 453–474, 1983.
6.
CompagnoJ., OertelJ.E.: Mucinous cystic neoplasm of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma).Am. J. Clin. Pathol., 69: 573–580, 1978.
7.
CubillaA.L., FitzgeraldP.L.: Tumours of exocrine pancreas.In: Atlas of tumor pathology, Vol. 19, pp. 53–59, Armed Force Institute of Pathology, Washington DC, 1984.
8.
GuillouL., NordbackP., GerberC., SchneiderR.P.: Ductal adenocarcinoma arising in a heterotopic pancreas situated in a hiatal hernia.Arch. Pathol. Lab. Med., 118: 568–571, 1994.
9.
HsuS.M., RaineL., FangerH.: Use of the avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques. A comparison between ABC and unlabeled antibody (PAP) procedures.J. Histochem. Cytochem., 29: 557–580, 1981.
10.
IshikawaO., IshiguroS., OhhigashiH., SasakiY., YasudaT., ImoakaS., IwanagaT., NakaizumiA., FujitaM., WadaA.: Solid and papillary neoplasm arising from an ectopic pancreas in the mesocolon.Am. J. Gastroenterol., 85: 597–601, 1990.
11.
MafasumiH., YutakaT.: Immunohistochemical studies of endocrine cells in heterotopic pancreas.Virchows Arch. (Pathol. Anat.), 408: 385–394, 1986.
12.
MiraccoC., DemartinoA., LioR., BottaG., VolterraniL., LuziP.: Splenic cyst lined with mucus-secreting epithelium -evidence of an intestinal origin.Arch. Anat. Cytol. Path., 34: 304–306, 1986.
13.
MorinagaS., OhyamaR., KoizumiJ.: Low-grade mucinous cystadenocarcinoma in the spleen.Am. J. Surg. Pathol., 16: 903–908, 1992.
14.
ShumanR.L., BouterieR.L.: Cystadenocarcinoma of the pancreas presenting as a splenic cyst.Surgery, 80: 652–654, 1976.