We report multiple malignancies in four patients with metachronous renal adenocarcinomas. The group of patients includes two women treated for primary breast and ovarian cancer and two men with prostate and colon cancer respectively. The occurrence of renal cancer following these primary solid tumors was not associated with previous treatments. The authors review the literature and discuss pathogenic mechanisms underlying renal cell carcinoma.
BeatyM.W., ZhuangZ., ParkW.S., Emmert-BuckM.R., Marston LinehanW., LubenskyI.A., AbatiA.: Fine-needle aspiration of metastatic clear cell carcinoma of the kidney.Cancer Cytopathology, 81: 180–186, 1997.
2.
BloomH.J.Medroxyprogesterone acetate (Provera) in the treatment of metastatic renal cancer.Br. J. Cancer, 25: 250–65, 1971.
3.
BloomH.J., RoeF.J., MatchleyB.C.: Sex hormones and renal neoplasia. Inhibition of tumor of hamster kidney by an estrogen antagonist, an agent of possible therapeutic value in man.Cancer, 20: 2118–2124, 1967.
4.
CurtisR.E., HooverR.N., KleinermanR.A., HarveyE.B.: Second cancer following cancer of the female genital system in Connecticut, 1935-82.Natl. Cancer Inst. Monogr.,68: 113–137, 1985.
5.
HarrisP., MortonC.C., GuglielmiP., LiF., KellyK., LattS.A.: Mapping by chromosome sorting of several gene probes, including c-myc, to the derivative chromosomes of a 3;8 translocation associated with familial renal cancer.Cytometry, 7: 589–594, 1986.
6.
HarveyE.B., BrintonL.A.: Second cancer following cancer of the breast in Connecticut, 1935-82.Natl. Cancer Inst. Monogr.,68: 99–112, 1985.
7.
HoarS.K., WilsonJ., BlotW.J., McLaughlinJ.K., WinnD.M., KantorA.F.: Second cancer following cancer of the digestive system in Connecticut, 1935-82.Natl. Cancer Inst. Monogr,68: 49–82, 1985.
8.
IgisuK., SekiY., OkaT., OharaK., TamakiK.: Four primary malignant tumors, including malignant melanoma and malignant lymphoma, in the same adult patient.J. Dermatol., 14: 170–174, 1987.
9.
KaldorJ.M., DayN.E., BandP., ChoiN.W., ClarkeE.A., ColemanM.P., HakamaM., KochM., LangmarkF., NealF.E., PettersonF., Pompe-KirnV., PriorP., StormH.H.: Second malignancies following testicular cancer, ovarian cancer and Hodgkin's disease: an international collaborative study among cancer registries.Int. J. Cancer, 39: 571–585, 1987.
10.
LucianiL.: The changing epidemiology of renal cell carcinoma. In: Basic research in urological oncology, LucianiL., De-bruyneF.M.J., SchalkenJ.A., pp. 124–134, Karger, Basel, 1996.
11.
TihanT., FilippaD.A.: Coexistence of renal cell carcinoma and malignant lymphoma. A causal relationship or coincidental occurrence?Cancer, 77: 2325–31, 1996.
12.
TravisL.B., CurtisR.E., BoiceJ.D.Jr., HankeyB.F., FraumeniJ.F.Jr.: Second cancers following non-Hodgkin's lymphoma.Cancer, 67: 2002–2009, 1991.
13.
TravisL.B., CurtisR.E., GlimeliusB., HolowatyE., Van LeeuwenF.E., LynchC.F., AdamiJ., GospodarowiczM., WacholderS., InskipP., TuckerM.A., FraumeniJ.F.jr, BoiceJ.D.: Second cancers among long-term survivors of non-Hodgkin's lymphoma.J. Natl. Cancer Inst.,85: 1932–1937, 1993.
14.
ZbarB., BrauchH., TalmadgeC., LinehanM.: Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma.Nature, 327: 721–724, 1987.