ClendenninN.J., CollierM.A., JohnstonA.L., LohK.K., CohnA., KellyK., GlobeL.M., StuartK.E., BelaniC.P.: Thymitaq™ (AG337): a novel thymidylate synthase inhibitor with clinical activity in solid tumours.Proc. Am. Assoc. Cancer Res.,37: 171, 1996.
2.
CunninghamD., ZalcbergJ., SmithI.E., GoreM., PazdurR., BurrisH.III, AzabM., KennealeyG.: Tomudex: a novel thymidylate synthase inhibitor with clinical antitumour activity in a range of solid tumours.Ann. Oncol.,5(suppl. 8) 179, 1994.
3.
JackmanA.L., BoyleF.T., HarrapK.R.: Tomudex (ZD1694): from concept to care, a programme in rational drug discovery.Inv. New Drugs, 14: 305–316, 1996.
4.
JackmanA.L., FarrugiaD.C., GibsonW., KimbellR., HarrapK.R., StephensT.C., AzabM., BoyleF.T.: ZD1694 (Tomudex): a new thymidylate synthase inhibitor with activity in colorectal cancer.Eur. J. Cancer,31A: 1277–1282, 1995.
5.
JackmanA.L., JudsonI.R.: The new generation of thymidylate synthase inhibitors in clinical study.Exp. Opin. Invest. Drugs, 5: 719–736, 1996.
6.
JackmanA.L., TaylorG.A., CalvertA.H., HarrapK.R.: Modulation of antimetabolite effects: effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB 3717.Biochem. Pharmacol., 33: 3269–3275, 1984.
7.
JackmanA.L., TaylorG.A., GibsonW., KimbellR., BrownM., CalvertA.H., JudsonI.R., HughesL.R., ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical studyCancer Res., 51: 5579–5586, 1991.
8.
JohnstonP.G., LenzH.J., LeichmanC.G., DanenbergK.D., AllegraC.I., DanenbergP.V., LeichmanL.: Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumours.Cancer Res., 55: 1407–1412, 1995.
9.
PetersG.J.: Antimetabolites. In: The scientific basis for cancer treatment, Oxford textbook of Oncology,PeckhamM., PinedoH., VeronesiU., Eds., pp. 524–552, Oxford University Press, Oxford, 1995.
10.
SchultzR., AndisS., ChenV., MendelsohnL., PatelV., ShihC., HoughtonJ.: Comparative antitumour activity of the multitargeted antifolate LY231514 and the thymidylate synthase inhibitor ZD1694.Annals of Oncology,7(suppl. 1) 85, 1996.
11.
SeitzJ.F., CunninghamD., RathU., OlverI.N., Van CutsemE., KerrD., SvenssonC., Perez MangaG., HarperP., ZalcbergJ., LoweryK., AzabM. for the Tomudex’ study group: Final results and survival data of a large randomized trial of Tomudex in advanced colorectal cancer confirm comparable efficacy to 5-fluorouracil plus leucovorin (5FU+LV).Proc. Am. Soc. Clin. Oncol.,15: 201, 1996.