Granular cell tumors have been described in many sites throughout the body. To our knowledge, few cases have been described in the literature. We report here the sixth case, in which positivity for lysozyme was also observed for the first time. The problems of the histogenesis and differential diagnosis of this rare variant of basal cell carcinoma are also discussed.
HartmanK.S.: Granular cell ameloblastoma. A survey of twenty cases from the Armed Forces Institute of Pathology. Oral Surg., 38: 241–253, 1974.
6.
KhansurT., BalducciL., TavassoliM.: Identification of desmosomes in the granular cell tumor. Implications in histologic diagnosis and histogenesis. Am. J. Surg. Pathol., 9: 898–904, 1985.
7.
LeBoitP.E., BarrR.J., BurallS., MetcalfJ.S., Benedict YenT.B., WickM.R.: Primitive polypoid granular cell tumor and other cutaneous granular-cell neoplasms of apparent nonneural origin. Am. J. Surg. Pathol., 15: 48–58, 1991.
8.
LeverW.F., Schaumburg-LeverG.: Histopathology of the skin, pp. 582–593, Lippincott, Philadelphia, 1990.
9.
McWilliamL.J., HarrisM.: Granular cell angiosarcoma of the skin: histology, electron microscopy and immunohistochemistry of a newly recognized tumor. Histopathology, 9: 1205–1216, 1985.
Rai MittalK., TrueL.D.: Origin of granules in granular cell tumor. Intracellular myelin formation with autodigestion. Arch. Pathol. Lab. Med., 112: 302–303, 1988.
12.
ReidbordH.E., WechslerH.L., FisherE.R.: Ultrastructural study of basal cell carcinoma and its variants with comments on histogenesis. Arch. Dermatol., 104: 132, 1971.
13.
RosaiJ. (Ed.): Ackerman's Surgical Pathology VII, vol. II, pp. 1609–1610, Mosby, St. Louis, 1989.