We describe the case of a patient with neuroblastoma and opsoclonus-myoclonus-ataxia displaying serum and CSF anti-Hu antibodies that were able to recognize antigens of the patient's own tumor.
AndersonN. E., Budde-SteffenC., RosenblumM.K., GrausF., FordD., SynekB.J.L., PosnerJ.B.: Opsoclonus, myoclonus, ataxia and encephalopathy in adults with cancer: a distinct paraneoplastic syndrome. Medicine, 67: 100–109, 1988.
2.
CaronH., Van SluisF., De KrakerJ., BokkerinkJ., EgelerM., LaureisG., SlaterR., WesterveldA., VouteP.A., VersteegR.: Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma. N. Engl. J. Med., 334: 225–230, 1996.
3.
DalmauJ., FurneauxH.M., Cordon-CardoC., PosnerJ.B.: The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuropathy) antigen in human normal and tumor tissues. Am. J. Pathol., 141: 881–886, 1992.
4.
DalmauJ., GrausF., RosenblumM.K., PosnerJ.B.: Anti-Hu associated paraneoplastic encephalomyelitis/sensory neuropathy: a clinical study of 71 patients. Medicine, 71: 59–72, 1992.
5.
DalmauJ., PosnerJ.B.: Neurologic paraneoplastic antibodies (anti-Yo; anti-Hu; anti-Ri): the case for a nomenclature based on antibody and antigen specificity. Neurology, 44: 2241–2246, 1994.
6.
DalmauJ., GrausF., CheungN-K. V., RosenblumM.K., HoA., CaneteA., DelattreJ-Y, ThompsonS.J., PosnerJ.B.: Major histocompatibility proteins, anti-Hu antibodies and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer, 75(1): 99–109, 1995.
7.
DropchoE.J.: Autoimmune aspects of paraneoplastic cerebellar degeneration. Progress in NeuroEndocrinImmunology, 3: 90–102, 1990.
8.
FisherP.J., WechslerD.S., SingerH.S.: Anti-Hu antibodies in a neuroblastoma-associated paraneoplastic syndrome. Ped. Neurol., 10: 309–312, 1994. 9. Furneaux H.F., Reich L., Posner J.B.: Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology, 40: 1085–1091, 1990.
9.
GreenleeJ.F., ParksT.N., JaeckleK.A.: Type IIa (“anti-Hu”) antineural antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology, 43: 2049–2054, 1993.
LennonV.A.: Paraneoplastic autoantibodies: the case for a descriptive generic nomenclature. Neurology, 44: 2236–2240, 1994.
12.
LottI., KinsbourneM.: Myoclonic encephalopathy in infants. In: Advances in neurology, Vol. 43. Myoclonus. FahnS., MarsdenC.D., Van WoertH.H. (Eds.), pp. 127–136, Raven Press, New York, 1986.
13.
LovbladK-O., BoucrautJ., BourdenetS., BurgerD., BernardD., RegliF., SteckA.J.: Sensory neuronopathy and small cell lung cancer: antineural antibody reacting with neuroblastoma cells. J. Neurol., 240: 327–332, 1993.
14.
LuqueF.A., FurneauxH.M., FerzigerR., RosenblumM.K., WrayS.H., ScholdS.C.Jr., GlantzM.J., JaeckleK.A., BiranH., LesserM., PaulsenW.A., RiverM.E., PosnerJ.B.: Anti-Ri: an antibody associated with paraneoplastic opsoclonus and breast cancer. Ann. Neurol., 29: 241–251, 1991.
15.
YaragiharaT., HambergerA.: A method for separation of Purkinje cell and granular cell-enriched fractions from rabbit cerebellum. Brain Res., 59:445–448, 1973.