Cytogenetic analysis on a 7-day-old culture of a fibrothecoma showed only numerical chromosome abnormalities: 57, XX, +4, +5, +6, +10, + 12, +12, +14, +17, +18, +19, +20. The finding of an extra copy of chromosome 12 in mesenchymal tumors, mostly benign and originating from the female genital tract, may possibly point towards their common embryonic origin.
Get full access to this article
View all access options for this article.
References
1.
BelloM.J., ReyJ.A.: Chromosome aberrations in metastatic ovarian cancer: relationship with abnormalities in primary tumors.Int. J. Cancer, 45: 50–54, 1990.
2.
CrickardK., MarinelloM.J., CrickardU., SatchidanandS.K., YoonessiM., CaglarH.: Borderline malignant serous tumors of the ovary maintained on extracellular matrix: evidence for clonal evolution and invasive potential.Cancer. Genet. Cytogenet., 23: 135–143, 1986.
3.
FletcherJ.A., GibasZ., DonovanK., Perez-AtaydeA., GenetstD., MortonC.C., LageJ.M.: Ovarian granulosastromal cell tumors are characterized by Trisomy 12.Am. J. Pathol., 138: 515–520, 1991.
4.
IharaT., OhamaK., SatohH., FujiiT., NomuraK., FujiwaraA.: Histologic grade and karyotype of immature teratoma of the ovary.Cancer, 54: 2988–2994, 1984.
5.
Kliechle-SchwarzM., PfleidererA., SreekantaiahC., BergerC.S., SandbergA.A., MedchillM.T.: Cluster of trisomy 12 to tumors of the female genitourinary tract.Cancer. Genet. Cytogenet., 54: 273–275, 1991.
6.
Knoerr-GaertnerH., SchuhmannR., KrausH., Uegele-KallhardtB.: Comparative cytogenetic and histologic studies on early malignant transformation in mesothelial tumors of the ovary.Hum. Genet., 35: 281–297, 1977.
7.
LeungW.Y., SchwartzP.E., NgH-t., Yang-FengT.L.: Trisomy 12 in benign fibroma and granulosa cell tumor of the ovary.Gynecol. Oncol., 38: 28–31, 1990.
8.
LimonJ., Dal CinP., SandbergA.A.: Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors.Cancer Genet. Cytogenet., 23: 305–313, 1986.
9.
MrózekK., NedoszytkoB., BabinskaM., MrózekE., HrabowskaM., EmerichJ., LimonJ.: Case Report. Trisomy of chromosome 12 in a case of thecoma of the ovary.Gynecol. Oncol., 36: 413–416, 1990.
10.
ParmleyT.: Embriology of the female genital tract. In: Blaustein's Pathology of The Female Tract, KurmanR.J. (Ed.), pp. 1–14, Springer-Verlag, New York, 1989.
11.
PeakmanD.C., MoretonM.F., RobinsonA.: Prenatal diagnosis: techniques used to help in ruling out maternal contamination.J. Med. Genet., 14: 37–39, 1977.
12.
PejovicT., HeimS., MandahlN., ElmforsB., FlodérusU.M., FurgyikS., HelmG., WillénH., MitelmanF.: Trisomy 12 is a consistent chromosomal aberration in begnin ovarian tumors. Genes, Chrom.Cancer, 2: 48–52, 1990.
SamuelsonJ., LeungW.Y., SchwartzP.E., NgH-t., Yang-FengT.L.: Trisomy 12 in various ovarian tumors of benign to low malignancy.Am. J. Hum. Genet., 47: Suppl. A16, 1990.
15.
SurtiU., HoffnerL., ChakravartiA., FerrellR.E.: Genetics and biology of human ovarian teratomas. I. Cytogenetic analysis and mechanism of origin.Am. J. Hum. Genet., 47: 635–643, 1990.
16.
TeyssierJ.R., AdnetJ.J., PigeonF., BajolleF.: Chromosomal changes in an ovarian granulosa cell tumor: similarity with carcinoma.Cancer. Genet. Cytogenet., 14: 147–152, 1985.
17.
Yang-FengT.L., KatzS.N., CacangiuM.L., SchwartzP.E.: Cytogenetic analysis of ependymoma and teratoma of the ovary.Cancer. Genet. Cytogenet., 35: 83–89, 1988.
18.
Yang-FengT.L., LiS., LeungW.Y., CarcangiuM.L., SchwartzP.E.: Trisomy 12 and K-ras-2 amplification in human ovarian tumors.Int. J. Cancer, 48: 678–681, 1991.
19.
YoungR.H., ScullyR.E.: Sex-cord-stromal, steroid cell and other ovarian tumors with endocrine, paraendocrine, and paraneoplastic manifestations. In: Blaustein's pathology of the Female Genital Tract, KurmanR.J. (Ed.), pp. 607–658, Springer-Verlag, New York, 1989.
20.
ZhouD.J., Gonzalez-CadavidN., AhujaH., BattiforaH., MooreG.E., ClineM.J.: A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas.Cancer, 62: 1573–1576, 1988.
