Thirty-four breast cancer patients with single brain metastases were reviewed: 9 underwent surgical removal only and 25 surgical removal and radiotherapy. A longer survival was seen in patients who underwent surgical removal and radiotherapy, with a mean survival of 28 months. In the 9 patients who did not receive whole brain radiotherapy, the mean survival was 15 months and there was an higher frequency of brain relapse.
CaimcrossJ.G., PosnerJ.B.: The management of brain metastases. In: Oncology of the Nervous System, WalkerM.D. (Ed.), pp. 341–377, Martinuus Njihoff, Boston, 1983.
5.
De AngelisL., MandellL.R., ThalerH.T., KimmelD.W., GalicichJ.H., FuksZ., PosnerJ.B.: The role of postoperative radiotherapy after resection of single brain metastases.Neurosurgery, 24: 798–805, 1989.
6.
DeeleyT.J., EdwardJ.M.R.: Radiotherapy in the management of cerebral secondaries from bronchial carcinoma.Lancet, 1: 1209–1213, 1968.
7.
Di StefanoA., YapH.Y., HortobagyiG.N., BlumenscheinG.R.: The natural history of breast cancer patients with brain metastases.Cancer, 44: 1913–1918, 1979.
HellmanS.: Principles of radiation therapy. In: Cancer: principles and Practise of Oncology, De VitaV.T., Hell-manS., RosembergS.A. (Eds.), pp. 227–255, J.B. Lippincott, Philadelphia, 1985.
10.
HotonJ.H., BaxterD.H., OlsonK.B.: The management of metastasis to the brain by irradiation and corticosteroids.AJR, 111: 334–336, 1971.
11.
KambyC., SorensenP.S.: Characteristic of patients with short and long survivals after delection of intracranial metastasis from breast cancer.J. Neuroncol., 6: 37–45, 1988.
12.
KamofskyD.A., BurchenalJ.H.: The clinical evaluation of chemotherapeutic agents. In: Evaluation of Chemotherapeutic Agents, MacLeod (Ed.), pp. 191–205, Columbia University Press, New York, 1949.
13.
KorzeniowskiS., SzpytmaT.: Survival of breast cancer patients with brain metastases treated by irradiation.J. Eur. Radiother., 8: 25–30, 1987.
14.
MandellL., HilarisB., SullivanM.: The treatment of single brain metastasis from non-oat cell lung carcinoma: surgery and radiation versus radiation therapy alone.Cancer, 58: 6416–6449, 1986.
15.
MarkesberyW.R., BrooksW.H., GuptaG.D.: Treatment for patients with cerebral metastasis.Arch. Neurol., 35: 754–756, 1978.
16.
OrderS.E., HellmanS., VonEssenC.F.: Improvement in quality of survival following whole-brain irradiation for brain metastasis.Radiology, 91: 149–153, 1968.
17.
PatchellR.A., CirrincioneC., ThalerH.T., GalicichJ.H., KimJ.H., PosnerJ.B.: Single brain metastases: surgery plus radiation or radiation alone.Neurology, 36: 447–453, 1986.
18.
SmalleyS.R., SchrayM.F., LawsE.R.Jr., O'FallonJ.R.: Adjuvant radiation therapy after surgical resection of solitary brain metastases: association with pattern of failure and survival.Int. Radiat. Oncol. Biol. Phys., 13: 1611–1616, 1987.
19.
SneeM.P., RodgerA., KerrG.R.: Brain metastasis from carcinoma of breast: a review of 90 cases.Clin. Radiol., 36: 365–367, 1985.
20.
WinstonK.R., WalshJ.W., FischerE.G.: Results of operative treatment of intracranial metastatic tumors.Cancer, 45: 2634–2645, 1980.
21.
YoungB., PatchellR.A.: Surgery for single brain metastases. In: Neurosurgery Update, WilkinsR.H., RengacharyS.S. (Eds.), pp. 473–476, McGraw-Hill, New York, 1990.
22.
ZimmS., WamplerG.L., StableinD.: Intracranial metastases in solid-tumor patients: natural history and results of treatment.Cancer, 48: 384–394, 1981.
