A case of acute monocytic leukemia with an apparent isolated skin relapse is reported. The cutaneous involvement was associated with a morphological bone marrow remission but a cytogenetic relapse was present. Regression of the skin lesions was obtained with a protocol including daunoblastine, aracytin and thioguanine, but the patient relapsed and died a few months later without achieving another remission. The relation between cutaneous and medullary disease is discussed.
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3.
Cordon-CardoC., O'BrienJ.P., CasalsD., Rittman-GrauerL., BiedlerJ.L., MelamedM.R., BertinoJ.R.: Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.Proc. Natl. Acad. Sci. USA, 86: 695–698, 1989.
4.
HaubenstockA., ZaluskyR., GhaliV.S., MernickM.H., MalamudS.C., SteinJ.J.: Isolated leukemia cutis.A case report. Am. J. Hematol., 24: 437–439, 1987.
5.
LeoneG., PaganoL., MarraR., LandolfiR., CudilloL., StortiS., MangoG., AlfanoG., D'OnofrioG.: Combination of 6-mercaptopurine, vincristine, methotrexate and prednisone in resistant or relapsed acute nonlymphoid leukemia.Cancer Treat. Rep., 71: 751–753, 1987.
MullerC.P., ZieglerA., SteinkeB., HornyH.P., WallerH.D.: Myelosarcomatosis of the skin preceding leukemic generalization of acute myelomonocytic leukemia.Blut, 58: 165–167, 1989.
8.
OzolsK.L., CowanK.: New aspects of clinical drug resistance: the role of gene amplification. In: Important Advances in Oncology 1986.De VitaV.T., HelmanS., RosembergS.A. (Eds.), pp. 129–157. J.B. Lippincott Comp., Philadelphia, 1987.
9.
PaganoL., MarraR., StotriS., PaolettiS., LeoneG.: Aggressive chemotherapy in the treatment of subacute myelomonocytic leukemia with skin infiltration.Br. J. Haematol., 67: 246–247, 1987.
10.
PreislerH., DavisR.B., KrishnerJ., EarlyA.P., BrowmanG., RazzaA., SteinA.M., FreemanA.: Comparison of three remission induction regimes and two postinduction strategies for the treatment of acute nonlymphocytic leukemia: a Cancer and Leukemia Group B Study.Blood, 69: 1441–1449, 1987.
11.
RubinC.M., ArthurD.C., MeyersG., McClainK.L., KimT.H., WoodsW.G.: Leukemia cutis treated with total skin irradiation.Cancer, 55: 2649–2652, 1985.
12.
StawskyM.: Skin manifestation of leukemias and lymphomas.Cutis, 21: 814–819, 1978.
