Adrenal cortical insufficiency secondary to destruction of the cortex by a metastatic tumor is a rare condition. Addison's disease is usually caused by an autoimmune process or by a tuberculous infection. We report a case of adrenal Insufficiency as the first clinical manifestation of a metastatic prostate carcinoma that occurred simultaneously with an active pulmonary infection by M. tuberculosis.
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References
1.
AbramsH.L., SpiroR., GoldsteinN.: Metastases in carcinoma: analysis of 1000 autopsied cases. Cancer, 3: 74–85, 1950.
2.
AldreteJ.S., BohrodM.G.: Adrenal metastases in cancer of the breast. Their prognostic significance when found at adrenalectomy. Am. Surg., 33: 174–178, 1967.
3.
AuerbachO., GarfinkelL., ParksV.R.: Histologic type of lung cancer in relation to smoking habits, year of diagnosis and sites of metastases. Chest., 67: 382–387, 1975.
4.
BullockW.K., HirstA.E.: Metastatic carcinoma of the adrenals. Am. J. Med. Sci., 226: 521–524, 1953.
5.
CareyR.W., HarrisN., KlimanB.: Addison's disease secondary to lymphomatous infiltration of the adrenal glands. Recovery of adrenocortical function after chemotherapy. Cancer, 59: 1087–1090, 1987.
6.
CedermakB.J., BlumensonL.E., PickrenJ.W., EliasE.G.: The significance of metastases to the adrenal gland from carcinoma of the stomach and esophagus. Surg. Gynecol. Obstet., 145: 41–48, 1977.
7.
CedermakB.J., BlumensonL.E., PickrenJ.W., HolyokeD.E.: The significance of metastases to the adrenal glands in adenocarcinoma of the colon and rectum. Surg. Gynecol. Obstet., 144: 537–546, 1977.
8.
CifuentesN., PickrenJ.W.: Metastases from carcinoma of mammary gland. An autopsy study. J. Surg. Oncol., 11: 193–205, 1979.
9.
EngelmanR.M., McNamaraW.L.: Bronchogenic carcinoma: a statistical review of two hundred and thirty-four autopsies. J. Thorac. Surg., 27: 227–237, 1954.
10.
GuttmanP.H.: Addison disease: a statistical analysis of five hundred and sixty-six cases and a study of the pathology. Arch. Pathol., 10: 742–895, 1930.
11.
HeusonJ.C.: Addison's disease secondary to occult metastatic seminoma. Infarction of the adrenals as the probable mechanism of their destruction. Cancer, 19: 1754–1759, 1966.
12.
HillG.J., WheelerH.B.: Adrenal insufficiency due to metastatic carcinoma of the lung: case report and review of Addison's disease caused by adrenal metastases. Cancer, 18: 1467–1473, 1965.
Sahagian-EdwardsA., HollandJ.F.: Metastatic carcinoma to the adrenal glands with cortical hypofunction. Cancer, 7: 1242–1245, 1954.
20.
SaitohH., HidaM., ShimboT., NakamuraK., YamagataJ., SatohT.: Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved. Cancer, 54: 3078–3084, 1984.
21.
TellD.T., KhouryJ.M., TaylorH.G., VeaseyS.P.: Atypical metastasis from prostate cancer. Clinical utility of the im-munoperoxidase technique for prostate-specific antigen. JAMA, 253(4): 3574–3575, 1985.
22.
VitaJ., SilverbergS., GolandR., AustinJ., KnowltonA.: Clinical clues to the cause of Addison's disease. Am. J. Med., 78: 461–466, 1985.
23.
WillisR.A.: Secondary tumors of the adrenal. In. The spread of tumors in the human body, p. 178. Butterworth, London, 1948.
