We describe a case of primary alveolar soft part sarcoma presenting as a vaginal mass in a 27 year old woman and also review the literature on this type of tumor arising in the lower female genital tract. Histologically, most of the tumor exhibited poorly developed alveolar architecture, but anaplasia was absent. Although the mass was well circumscribed, a few tumor cells were seen focally within the peritumoral tissue. Treatment consisted of wide local excision followed by external radiation therapy. The patient is alive without evidence of disease 17 years after operation.
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References
1.
AuerbachH.E., BrooksJ.J.: Alveolar soft part sarcoma. A clinicopathologic and immunohistochemical study. Cancer, 60: 66–67, 1987.
2.
ChapmanG.W., BendaJ., WilliamsT.: Alveolar soft-part sarcoma of the vagina. Gynecol. Oncol., 18: 125–129, 1984.
3.
DavosI., AbellM.R.: Sarcomas of the vagina. Obstet. Gynecol., 47: 342–350, 1976.
4.
DenkH., KrepierR., ArtliebU., GabbianiG., Rungger-BrandeE., LeonciniP., FrankeW.W.: Proteins of intermediate filaments. An immunohistochemical and biochemical approach to the classification of soft tissue tumors. Am. J. Pathol., 110: 193–208, 1983.
5.
EnzingerF.M.: Alveolar soft-part sarcoma, case 23. In: Proceedings of the 39th Annual Anatomic Pathology Seminar of the Am. Soc. Clin. Pathol., HartmannW.H. (Ed.), Chicago ASCP, 123–127, 1973.
6.
EnzingerF.M., WeissS.W.: Malignant tumors of uncertain histogenesis. In: Soft Tissue Tumors.The C.V. Mosby Co., St. Louis, 780–787, 1983.
7.
EvansH.L.: Alveolar soft-part sarcoma. A study of 13 typical examples and one with a histologically atypical component. Cancer, 55: 912–917, 1985.
8.
FlintA., GikasP.W., RobertsJ.A.: Alveolar soft part sarcoma of the uterine cervix. Gynecol. Oncol., 22: 263–267, 1985.
9.
FoschiniM.P., CeccarelliC., EusebiV., SkalliO., GabbianiG.: Alveolar soft part sarcoma: immunological evidence of rhabdomyoblastic differentiation. Histopathology, 13: 101–108, 1988.
10.
FoschiniM.P., TisonV., EusebiV.: Alveolar soft part sarcoma of the cervix uteri: a case report. Pathol. Res. Pract., 184: 354–358, 1989.
11.
GrayG.F., GlickA.D., KurtinP.I., JonesH.W.III: Alveolar soft part sarcoma of the uterus. Hum. Pathol., 17: 297–300, 1988.
12.
KasaiK., YoshidaY., OkumuraM.: Alveolar soft part sarcoma in the vagina, clinical features and morphology. Gynecol. Oncol., 9: 227–236, 1980.
13.
LattesR.: Tumors of the soft tissue. In: Atlas of Tumor Pathology. Armed Forces Institute of Pathology, Fascicle I, 2nd series (Revised), Washington D.C., 251–254, 1985.
MukaiM., TorikataC., IriH., MicataA., HanaokaH., KatoK., KageyamaK.: Histogenesis of alveolar soft part sarcoma. An irnmunohistochemical and biochemical study. Am. J. Surg. Pathol., 10: 212–218, 1986.
16.
OrdonezN.G., HickeyR.C., BrooksT.E.: Alveolar soft part sarcoma. A cytologic and immunohistochemical study. Cancer, 61: 525–531, 1988.
17.
O'TooleR.V., TuttleS.E., LucasJ.G., SharmaH.M.: Alveolar soft part sarcoma of the vagina: An irnmunohistochemical and electron microscopic study. Int. J. Gynecol., Pathol., 4: 258–265, 1985.
18.
PetersW.A.III, KumarN.B., AndersenW.A., MorleyG.W.: Primary sarcoma of the adult vagina: A clinicopathologic study. Obstet. Gynecol., 65: 699–704, 1985.
19.
ShenJ., D'AblaingG., MorrowC.P.: Alveolar soft part sarcoma of the vulva: Report of first case and review of the literature. Gynecol. Oncol., 13: 120–128, 1982.
20.
StoutA.P., LattesR.: Tumors of the soft tissue. In: Atlas of Tumor Pathology. Armed Forces Institute of Pathology, Fascicle I, 2nd series, Washington D.C., 181, 1967.
