We describe two patients with lung carcinoma in whom adrenal glands were the sole site of tumor relapse, revealed by the appearance of Addison's disease. Both patients showed bilateral adrenal masses on US and/or CAT scans and received hormone replacement therapy, with rapid improvement of their general conditions. One of them, with small-cell carcinoma, could also be treated with further chemotherapy and achieved a second remission. Therefore, we stress that patients with lung carcinoma should be periodically screened for adrenal deposits by US or CAT and undergo prophylactic steroid maintenance whenever metastatic involvement of the glands is detected.
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References
1.
AbramsH.L., SpiroG., GoldsteinN.: Metastases in carcinoma: analysis of 1000 autopsied cases.J. Urol.,81: 711–719, 1959.
2.
BernardinoM.E., GoldsteinH.N., GreenB.: Gray scale ultrasonography of adrenal neoplasms.Am. J. Roentgenol.,130: 741–744, 1978.
BullockW.K., HirstA.E.: Metastatic carcinoma of the adrenal.Am. J. Med. Sci.,226: 521–524, 1953.
5.
EnglemanR.M., McNamaraW.L.: Bronchogenic carcinoma. A statistical review of 234 autopsies.J. Thorac. Surg.,27: 227–237, 1954.
6.
ForsytheJ.R., GasinkB.B., LeopoldG.R.: Ultrasound in the evaluation of adrenal metastases.J. Clin. Ultrasound,5: 31–34, 1977.
7.
GlomsetD.A.: The incidence of metastases of malignant tumours to the adrenals.Am. J. Cancer,32: 57–61, 1938.
8.
HillJ., WheelerH.B.: Adrenal insufficiency due to metastatic carcinoma of the lung. Case report and review of Addison's disease caused by adrenal metastases.Cancer,18: 1468–1473, 1965.
9.
KarstaedtN., SagelS.S., StanleyR.G., MelsonG.L., LevittR.G.: Computed tomography of the adrenal gland.Radiology,129: 723–730, 1978.
10.
KhanA., KhanF.A., MehraS., TafreshiM.: Addison's disease due to metastatic carcinoma: the value of CT scan.Comput. Radiol.,7: 369–371, 1983.
11.
KorobkinM., WhiteE.A., KresselH.Y., MossA.A., MontagneJ.P.: Computed tomography in the diagnosis of adrenal disease.Am. J. Roentgenol.,132: 231–238, 1979.
SandlerM.A., PearlbergJ.L., MadrazoB.L., GitschlagK.F., GrossS.C.: Computed tomographic evaluation of the adrenal gland in the preoperative assessment of bronchogenic carcinoma.Radiology,145: 733–736, 1982.
19.
SeidenwurmD.J., ElmerE.B., KaplanL.M., WilliamsE.K., MorrisD.G., HoffmanA.R.: Metastases to the adrenal glands and the development of Addison's disease.Cancer,54: 552–557, 1984.
20.
SheelerL.R., MyersJ.H., EversmanJ.J., TaylorH.C.: Adrenal insufficiency secondary to carcinoma metastatic to the adrenal gland.Cancer,52: 1312–1316, 1983.
21.
SiekavizzaJ.L., BernardinoM.E., SamaanN.A.: Suprarenal mass and its differential diagnosis.Urology,18: 625–632, 1981.
22.
ViewegW.V.R., ReitzR.E., WeinsteinR.I.: Addison's disease secondary to metastatic carcinoma: an example of adrenocortical and adrenomedullary insufficiency.Cancer,31: 1240–1243, 1973.
