A study of the relative 2dG6P utilization in mononuclear cells from a group of 150 women with breast cancer was undertaken to evaluate a possible negative correlation between G6PD deficiency and cancer, as suggested by some authors. Twenty-one women (14.00 %) were heterozygotes and 2 were homozygotes (1.33 %). The prevalence found was not different from that expected. It would therefore seem that the G6PD Mediterranean allele does not play a protective role against the development of breast cancer.
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References
1.
AddisS.: Distribuzione della deficienza in glucosio-6-fosfato deidrogenasi tra pazienti ricoverati nell'Ospedale Civile di Sassari.Applicazioni bio-mediche del calcolo elettronico, 4: 230–235, 1971.
2.
BeaconsfieldP., RainsburyR., KaltonG.: Glucose-6-phosphate dehydrogenase and the incidence of cancer.Oncologia, 19: 11–19, 1965.
3.
CoccoP.: Does G6PD deficiency protect against cancer? A critical review.J. Epidemiol. Comm. Health., 41: 89–93, 1987.
4.
CoccoP., MancaP., DessiS.: Preliminary results of a geographic correlation study of G6PD deficiency and cancer.Toxicol. Pathol., 15: 106–108, 1987.
5.
FerrarisA.M., BrocciaG., MeloniT., ForteleoniG., GaetaniG.F.: Glucose-6-phosphate dehydrogenase deficiency and incidence of hematologic malignancy.Am. J. Hum. Genet., 42: 516–521, 1988.
6.
FerrarisA.M., GiuntiniP., GalianoS., GaetaniG.F.: 2-Deoxyglucose-6-phosphate utilization in the study of glucose-6-phosphate dehydrogenase mosaicism.Am. J. Hum. Genet., 33: 307–313, 1981.
7.
GaetaniG.F., FerrarisA.M., GalianoS., GiuntiniP., CanepaL., D'UrsoM.: Primary thrombocythemia: clonal origin of platelets, erythrocytes and granulocytes in a GD B/GD Med subject.Blood, 59: 76–79, 1982.
8.
MeloniT., CutilloS., TestaU., LuzzatoL.: Neonatal jaundice and severity of glucose-6-phosphate dehydrogenase deficiency in Sardinian babies.Early. Hum. Dev., 15: 317–322, 1987.
9.
NaikS.N., AndersonD.E.: The association between glucose-6-phosphate dehydrogenase and cancer in American Negroes.Oncology, 25: 356–364, 1971.
10.
PiomelliS.: G6PD deficiency and related disorders of the pentose pathway. In: Hematology of Infancy and Childhood, NathanD.G., OskiF.A. (Eds.), 3rd edn., pp. 589–612, W.B. Saunders, Philadelphia, 1987.
11.
SulisE.: G6PD deficiency and cancer.Lancet, 1: 1185, 1972.
12.
ThompsonG.S., ThompsonM.W.: Genetics in medicine.3rd edn., pp. 290–308, W.B. Saunders, Philadelphia, 1980.
