Polyamine oxidase (PAO) activity was determined in the serum of cancer patients and healthy subjects. However, the data obtained showed that PAO activity was extremely low or undetectable in the serum of cancer patients and healthy subjects. The difference in PAO activity observed between the sera of cancer patients and healthy subjects was statistically insignificant. Thus, the measurement of PAO activity in serum has no value as a cancer marker.
Get full access to this article
View all access options for this article.
References
1.
DreyfussF., ChayenR., DreyfussJ., DvirR., RatonJ.: Polyamine excretion in the urine of the cancer patients.Isr. J. Med. Sci., 11: 785–788, 1975.
2.
DurieB.G.M., SalmonS.E., RussellD.H.: Polyamines as markers of response and disease activity in cancer chemotherapy.Cancer Res., 37: 214–221, 1977.
3.
HirschJ.G.: Spermine oxidase: an amine oxidase with specificity for spermine and spermidine.J. Exp. Med., 97: 345–355, 1953.
4.
HölttäE.: Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase.Biochemistry, 16: 91–100, 1977.
5.
LiptonA., SheehanL.M., KesslerG.F.: Urinary polyamine levels in human cancer.Cancer, 35: 464–468, 1975.
6.
LowryO.H., RosebroughN.J., FarrA.L., RandallR.J.: Protein measurement with the Folin phenol reagent.J. Biol. Chem., 193: 265–275, 1951.
7.
MorganD.M.L., IlleiG.: Radiochemical estimation of serum polyamine oxidase activity in human pregnancy.Med. Lab. Sci., 38: 49–56, 1981.
8.
MorganD.M.L., FerlugaJ., AllisonA.C.: Polyamine oxidase and macrophage function. In: Polyamines in Biomedical Research.GaugasJ.M. (ed.), pp. 303–308, Wiley, Chichester, 1980.
9.
RomanoM., BonelliP.: Polyamine oxidase activity in carcinoma-bearing human breast: significant decreased activity in carcinomatous tissue.Tumori, 72: 31–33, 1986.
10.
RomanoM., CeccoL., CerraM., MontuoriR., De RosaC.: Polyamines as biological markers of the effectiveness of therapy in acute leukemia.Tumori, 66: 677–687, 1980.
11.
RomanoM., CeccoL., CerraM., De MatteisA.: Polyamine excretion as prognostic marker in radiologic therapy of breast carcinoma in metastatic phase. In: « Advances in Polyamine Research ». BachrachU., KayeA., ChayenR. (eds.), vol. 4r59–64, Raven Press, New York, 1983.
RussellD.H.: Increased polyamine concentration in the urine of human cancer patients.Nature:233: 144–145, 1971.
14.
RussellD.H., DurieB.G.M., SalmonS.E.: Polyamines as predictor of success and failure in cancer chemotherapy.Lancet, 2: 797–799, 1975.
15.
RussellD.H.: Clinical relevance of polyamines as biochemical markers of tumor kinetics.Review Clin. Chem., 23: 22–27, 1977.
16.
ScalabrinoG., FerioliM.A.: Polyamines in mammalian tumors.Adv. Cancer Res., 36: 1–102, 1982.
17.
WilcoxonF.: Verification statistique de l'homogéneit4eA de deux ou plusieurs échantillons. In: Étudestatistique des dépendances.95–99, AivazianS., Edition de Moscow, 1970.