The immnuohistochemical determination of immunoglobulins IgA, IgG and IgM in axillary lymph nodes from 50 unselected breast ductal carcinomas disclosed that lymph nodes with IgG-positive lymphoid follicles and/or metastasized lymph nodes with IgM-positive lymphoid cells are statistically related to breast tumors with a high histologic grade and more than 3 lymph node metastases.
Get full access to this article
View all access options for this article.
References
1.
BergJ.W.: Sinus histiocytosis: A fallacious measure of host resistence to cancer.Cancer, 9: 935–939, 1956.
2.
BlackM.M,. OplerS.R., SpeerF.D.: Survival in breast cancer cases in relation to the structure of the primary tumor and regional lymph nodes.Surg. Gynecol. Obstet., 100: 543–551, 1955.
3.
BrownleeK.A.: Statistical Theory and Methodology.Second edition, pp. 163–166, John Wiley and Sons, New York, 1965.
4.
Di ReJ.J., LaneN.: The relation of sinus histiocytosis in axillary lymph nodes to surgical curability of carcinoma of the breast.Am. J. Clin. Pathol., 40: 508–515, 1963.
5.
FisherB., RadinR.G., AusmanR.K., SlackN.H., MooreG.E., NoerR.J.: Surgical adjuvant chemotherapy in cancer of the breast: Results of a decade of cooperative investigation.Ann. Surg., 168: 337–356, 1968.
6.
FisherB., SlackN.H.: Number of lymph nodes examined and the prognosis of breast cancer.Surg. Gynecol. Obstet., 131: 79–88, 1970.
7.
FisherB., BauerM., WickerhamD.I., RedmondC.K., FisherE.R.: Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer.Cancer, 52: 1551–1557, 1983.
8.
FisherE.R., ReidbordH., FisherB.: Studies concerning the regional lymph node in cancer. V. Histologic and ultranstructural findings in regional and nonregional nodes.Lab. Invest., 28: 128–133, 1973.
9.
FisherE.R., RedmondC.K., LiuH., RicketteH., FisherB.: Correlation of estrogen receptor and pathologic characteristics of invasive breast cancer.Cancer, 45: 349–353, 1980.
10.
FisherE.R., SassR., FisherB.: Pathologic findings from the National Surgical Adjuvant Project for Breast Cancer (Protocol No. 4).Cancer, 53: 712–723, 1984.
11.
HartveitF.: The sinus reaction in the axillary nodes in breast cancer related to tumor size and nodal state.Histopathology, 6: 753–764, 1982.
12.
LeeY.T.N., RichtersA.: Axillary lymph nodes and serum immunoglobulins in breast cancer.J. Am. Med. Worn. Assoc., 32: 455, 1977.
13.
LeeY.T.N., RichtersA.: Axillary IgM (+) lymphocytes in breast cancer.Eur. J. Cancer, 16: 167, 1980.
14.
MorrisH.B., MasonD.Y., SteinH., LennertK.: An immunohistological study of reactive lymphoid tissue.Histopathology, 7: 809–823, 1983.
15.
RichtersA., KasperskyC.L.: Surface immunoglobulin positive lymphocytes in human breast cancer tissue and homolateral axillary lymph nodes.Cancer, 35: 129–133, 1975.
ThoresenS., HartveitF., TangenM., HalvorsenJ.F.: Sinus catarrh and histological grade in breast cancer.Histopathology, 7: 753–757, 1983.
18.
Urdiales-ViedmaM., Nogales-FernandezF., Martos-PadillaS., Sanchez-CantalejoE.: Correlation of histologic grade and lymph node status with some histopathologic discriminants in breast cancer.Tumori, 72: 75–83, 1986.
