A case of pernicious anemia associated with multiple gastric carcinoids is reported. The neoplastic growth was composed of enterochromaffin-like (ECL) cells, and ECL cell hyperplasia was observed also in hyperplastic polyps, inside the fundic glands and in small nests lying in the lamina propria (microcarcinoidosis). The possible relation between pernicious anemia and ECL cell hyperplasia is discussed.
Get full access to this article
View all access options for this article.
References
1.
BorchK., RenvallH., LiedbergG.: Gastric endocrine cell hyperplasia and carcinoid tumors in pernicious anemia.Gastroenterology, 88: 638–648, 1985.
2.
BordiC., CocconiG., TogniR., VezzadiniP., MissaleG.: Gastric endocrine cell proliferation in association with Zollinger-Ellison syndrome.Arch. Pathol., 98: 274–279, 1974.
CarneyJ.A., GoV.L.W., FairbanksV.F., MooreS.B., AlportE.C., NoraF.E.: The syndrome of gastric argyrophil carcinoid tumors and nonantral gastric atrophy.Ann. Int. Med., 99: 761–766, 1983.
8.
CreutzfeldtW., CreutzfeldtC., ArnoldR.: The gastrin-producing cells under normal and pathological conditions.Rendic. Gastroenterol., 7: 93–109, 1975.
9.
ElsborgL., AnderssonD., Myhre-JensenO., Ba-strup-MadsenP.: Gastric mucosal polyps in pernicious anaemia.Scand. J. Gastroenterol., 12: 49–52, 1977.
10.
GodwinJ.: Carcinoid tumors. Analysis of 2837 cases.Cancer, 36: 560–569, 1975.
11.
HajduS.I., WinawerS.J., MyersW.P.L.: Carcinoid tumors. A study of 204 cases.Am. J. Clin. Pathol., 61: 521–528, 1974.
12.
HäkansonR., LarssonL.I., LiedbergG., OscarsonJ., SundlerF., VangJ.: Effects of antrectomy or porta-caval shunting on the histamine-storing endocrine-like cells in oxyntic mucosa of rat stomach.J. Physiol., 259: 785–800, 1976.
HodgesJ.R., IsaacsonP., WrightR.: Diffuse en-terochromaffin-like (ECL) cell hyperplasia and multiple gastric carcinoids: a complication of pernicious anaemia.Gut, 22: 237–241, 1981.
15.
KaplanH.S., RiglerL.G.: Pernicious anemia and carcinoma of the stomach. Autopsy study concerning their interrelationship.Am. J. Med. Sci., 209: 339–348, 1945.
16.
LarssonL.I., RehfeldJ.F., StockbrüggerR., BlohmeG., SchöönI.M., LundqvistG., KindblomL.G., Säve-SöderbergJ., GrimeliusL., OlbeL.: Mixed endocrine gastric tumors associated with hypergastrinemia of antral origin.Am. J. Pathol., 93: 53–61, 1978.
17.
McDonaldR.A.: A study of 356 carcinoids of the gastrointestinal tract.Am. J. Med., 21: 867–878, 1956.
18.
MosbechJ., VidebaekA.: Mortality from and risk of gastric carcinoma among patients with pernicious anaemia.Br. Med. J., 2: 390–394, 1950.
19.
PolakJ.M., StaggB., PearseA.G.E.: Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies on the antral and pancreatic gastrin cells in different clinical states.Gut, 13: 501–512, 1972.
20.
Saint-AndrèJ.P., D'AubiguyN., BoualiA.B., Goe-thalsG., SimardC.: Gastrite chronique atrophique avec tumeur carcinoide et « microcarcinoidose ».Ann. Pathol., 3: 235–240, 1983.
SloanJ.M., BuchanamK.D., McFarlandR.J., TitteringtonP., SandfordJ.C.: A histological study of the effect of chronic gastritis on gastrin cell distribution in the human stomach.J. Clin. Pathol., 32: 201–207, 1979.
23.
SolciaE., CapellaC., BuffaR., UselliniL., FrigerioB., FontanaP.: Endocrine cells of the gastrointestinal tract and related tumors.Pathobiol. Annu., 9: 163–203, 1979.
24.
SolciaE., CapellaC., BuffaR., UselliniL., FioccaR., FrigerioB., TentiP., SessaF.: The diffuse endocrine-paracrine system of the gut in health and disease: ultrastructural features.Scand. J. Gastroenterol., 16(suppl. 70): 25–36, 1981.
25.
SternbergerL.A.: The unlabeled antibody peroxi-dase-antiperoxidase (PAP) method. In: Immuno-cytochemistry, pp. 104–159, John Wiley & Sons, New York, Chichester, Brisbane, Toronto, 1979.
26.
StockbrüggerR.W., MenonG.G., BeilbyJ.O.M., MasonR.R., CottonP.B.: Gastroscopic screening in 80 patients with pernicious anaemia.Gut, 24: 1141–1147, 1983.
27.
VassalloG., CapellaC., SolciaE.: Endocrine cells of the human gastric mucosa.Z. Mikrosk. Anat. Forsch., 118: 49–67, 1971.