The authors describe 2 cases of acute myeloid leukemia (AML) with ovarian granulocytic sarcoma (GS) and central nervous system (CNS) involvement. The patients had an unfavorable clinical course in a short period of time. It has been reported that GS or CNS involvement does not have a bad prognostic significance. We suggest that the association of these two complications worsens the prognosis of AML.
Get full access to this article
View all access options for this article.
References
1.
BallonS.C., DonaldsonR.C., BermanM.L., SwansonG.A., ByronR.L.: Myeloblastoma (granulocytic sarcoma) of the ovary. Arch. Pathol. Lab. Med., 102: 474–476, 1978.
GralnickH.R., DittmarK.: Development of myeloblastoma with massive breast and ovarian involvement during remission in acute leukemia. Cancer, 24: 746–749, 1969.
LiuP.I., IshimaruT., McGregorD.H.: Autopsy study of granulocytic sarcoma (chloroma) in patients with myelogenous leukemia: Hiroshima-Nagasaki 1949–1969. Cancer, 31: 948–955, 1973.
6.
LuciaS.P., MillsH., LowenhauptE., HuntM.L.: Visceral involvement in primary neoplastic diseases of the reticuloendothelial system. Cancer, 5: 1195–1200, 1952.
7.
McCartyK.S., WortmanJ., DalyJ., RundlesR.W., HankerJ.S.: Chloroma (granulocytic sarcoma) without evidence of leukemia: facilitated light microscopic diagnosis. Blood, 56: 104–109, 1980.
8.
MorganE.R., LobotkaR.J., Gonzales-CrussiF., WiederholdM., ShermanJ.O.: Ovarian granulocytic sarcoma as the primary manifestation of acute leukemia infantile mvelomonocytic. Cancer, 48: 1819–1824, 1981.
9.
MussH.B., MoloneyW.C.: Chloroma and other myeloblastic tumors. Blood, 42: 721–728, 1973.
10.
NeimanR.S., BarcosM., BerardC., BounerM., MannR., RydellR.E., BennettJ.M.: Granulocytic sarcoma: a clinico-pathologic study of 61 biopsied cases. Cancer, 48: 1426–1430, 1981.
11.
PeturssonS.R., BoggsD.R.: Spinal cord involvement in leukemia: a review of the literature and a case of Ph+ acute myeloid leukemia presenting with a Conus Medullaris syndrome. Cancer, 47: 346–350, 1981.
12.
StewartD.J., KeatingM.J., McCredieK.B., SmithT.L., YounessE., MurphyS.G., BodeyG.P., FreireichE.J.: Natural history of central nervous system acute leukemia in adults. Cancer, 47: 184–196, 1981.
