The carcinogenic and cocarcinogenic action of phenobarbital sodium was investigated in adult BALB/c mice of both sexes when administered alone at a concentration of 0.05 % in drinking water for life or after the animals had been treated with a single hydrazine sulphate dose of 5.65 mg. The results demonstrated that phenobarbital sodium is not carcinogenic in this strain of mice, but, since a single dose of hydrazine sulphate was carcinogenic, does not clarify whether it is a cocarcinogen in the lung.
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References
1.
BeckerF.F.: Morphological classification of mouse tumors based on biological characteristics.Cancer Res., 42: 3918–3923, 1982.
2.
BiancifioriC., Giornelli SantilliF.E., MiliaU., BucciarelliE.: Histogenesis of pulmonary tumours by hydrazine sulphate in BALB/c/Cb/Se substrain mice. In: Lung Tumours in Animals, pp. 881–895, Ed. by SeveriL., Division of Cancer Research, Perugia, 1966.
3.
BucciarelliE., RibacchiR.: C-type particles in primary and transplanted tumors induced in BALB/c/Cb/Se mice by hydrazine sulfate: electron microscopic and immunodiffusion studies.J. Natl. Cancer Inst., 49: 673–684, 1972.
4.
ClemmesenJ., Fuglsang-FrederiksenV., PlumC.M.: Are anticonvulsants oncogenic?Lancet, 1: 705–707, 1974.
5.
GoldE., GordisL., TonasciaJ., SzkloM.: Increased risk of brain tumors in children exposed to barbiturates.J. Natl. Cancer Inst., 61: 1031–1034, 1978.
6.
KitagawaT., HirakawaT., IshikawaT., NemotoN., TakayamaS.: Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.Toxicol. Lett., 61: 167–171, 1980.
7.
KunzW., SchaudeG., ThomasC.: Die Beeinflussung der Nitrosaminocarcinogenese durch Phenobarbital und Halogenkohlenwasserstoffe.Z. Krebsforsch., 72: 291–304, 1969.
8.
McLeanA.E.M., MarshallA.: Reduced carcinogenic effects of aflatoxin in rats given phenobarbitone.Br. J. Exp. Pathol., 52: 322–329, 1971.
9.
PerainoC., FryR.J.M., StaffeldtE.: Reduction and enhancement by phenobarbital of hepatocarcino-genesis induced in the rat by 2-acetylaminofluorene.Cancer Res., 31: 1506–1512, 1971.
10.
PerainoC., FryR.J.M., StaffeldtE.: Enhancement of spontaneous hepatic tumorigenesis in C3H mice by dietary phenobarbital.J. Natl. Cancer Inst., 51: 1349–1350, 1973.
11.
PerainoC., FryR.J.M., StaffeldtE., ChristopherJ.P.: Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin and dichloro-diphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.Cancer Res., 35: 2884–2890, 1975.
12.
PetoR., PikeM.C., ArmitageP., BreslowN.E., CoxD.R., HowardS.V., MantelN., McPhersonK., PetoJ., SmithP.G.: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples.Br. J. Cancer, 35: 1–39, 1977.
13.
PetoR., PikeM.C., DayN.E., GrayR.G., LeeP.N., ParishS., PetoJ., RichardsS., WahrendorfJ.: Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Suppl. 2. Long-term and short-term screening assays for carcinogens: A critical appraisal. pp. 311–426, IARC, Lyon, 1980.
14.
PonomarkovV., TomatisL., TurusovV.: The effect of long-term administration of phenobarbitone in CF-1 mice.Cancer Lett., 1: 165–172, 1976.
15.
RossiL., RaveraM., RepettiG., SantiL.: Long-term administration of DDT or phenobarbital-Na in Wistar rats.Int. J. Cancer, 19: 179–185, 1977.
16.
ThorpeE., WalkerA.I.T.: The toxicology of dieldrin (HEOD). II. Comparative long-term oral toxicity studies in mice with dieldrin, DDT, phenobarbitone, β-BHC and y-BHC.Fd. Cosmet. Toxicol., 11: 433–442, 1973.
17.
UchidaE., HironoI.: Effect of phenobarbital on the development of neoplastic lesions in the liver of cycasin-treated rats.J. Cancer Res. Clin. Oncol., 100: 231–238, 1981.
18.
WeisburgerJ.H., MadisonR.M., WardJ.M., VigueraC., WeisburgerE.K.: Modification of diethyl-nitrosamine liver carcinogenesis with phenobarbital but not with immunosuppression.J. Natl. Cancer Inst., 54: 1185–1188, 1975.
