We report a case of a patient with colon carcinoma and liver metastasis who presented chest pain after 5-fluorouracil (5-FU) administration. Clinical electrocardiographic evolution was similar to that observed in Prinzmetal's angina, and chest pain promptly resolved with nifedipine. These data suggest that coronary spasm may be the cause of cardiotoxicity due to 5-FU, and that calcium antagonists may probably be used in the prevention or treatment of 5-FU cardiotoxicity.
DentR.G., McCollL.: 5-FU and angina.Lancet, 1: 347–348, 1975.
4.
LabiancaR., BerettaG., ClericiM., FraschiniP., LuporiniG.: Cardiac toxicity of 5-Fluorouracil: a study on 1083 patients.Tumori, 68: 505–510, 1982.
5.
Lang StevensonD., MikhalidisD.P., GillettD.S.: Cardiotoxicity of 5-Fluorouracil.Lancet, 2: 406–407, 1977.
6.
LissR.H., ChadwikM.: Correlation of 5-Fluorouracil distribution in rodents with toxicity and chemotherapy in man.Cancer Chemother. Rep., 58: 777–786, 1974.
7.
ManenteP., BuchbergerR., ValmachinoG., FiorettiD., Lo GiudiceC., GasparoniP., ConteN.: Cardiotossicità da 5-Fluorouracile: descrizione di un caso clinico.Tumori, 66: 255–260, 1980.
