In menstruating 20-29 year old breast cancer patients, the total estrogen level showed a significant increase in the early follicular phase compared to normal healthy subjects. Such a difference was not observed in 30-45 year-old patients. A nonsignificant decrease was observed in the estradiol level of premenopausal breast cancer patients compared to normal healthy subjects. However, in postmenopausal breast cancer patients, the total estrogen level as well as the estradiol level showed a signicant increase compared to that of normal healthy subjects.
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References
1.
AndersonS.E.: Breast cancer in families.Cancer Bull., 25: 23, 1973.
2.
BulbrookE.D.: In: Breast cancer.Trends in Research and Treatment.HeusonJ.C., MattheiemW.H., RozencweigM.D. (eds.), p. 271. Raven Press, New York, 1976.
3.
BulbrookR.D., MooreJ.W., ClarkC.M.G., WangD.Y., TongD., HaywardJ.L.: Plasma estradiol and progesterone levels in women with varying degrees of risk of breast cancer.Eur. J. Cancer., 14: 1369–1375, 1978.
4.
BusterJ.E., AbrahimG.E.: The application of steroid hormone radioimmunoassay to clinical obstetrics.Obstet. Gynecol., 46: 489–497, 1975.
5.
CerianiR.L.: Hormones and other factors controlling growth in the mammary gland.J. Invest. Dermatol., 63: 93–95, 1974.
6.
DewaardF.: Breast cancer incidence and nutritional status with particular reference to body weight and height.Cancer Res., 35: 3351–3357, 1975.
7.
FraftaD., SchindlerA.E., MilcuS.M., KellerE., StoreE., HorodniceanuE., BalanescuI.: Plasma hormones in pre- and postmenopausal breast cancer.J. Steroid Biochem., 13: 793–802, 1980.
8.
IbrahimA.S.: Breast cancer: Epidemiology and risk factors.J. Egypt. Natl. Cancer Inst., 1: 13–25, 1982.
9.
JuretP., CouetteJ.E., BruneE., VernhesJ.C.: Age at first bitrh, an equivocal factor in human mammary carcinogenesis.Eur. J. Cancer, 10: 591–601, 1974.
10.
MacMahonB., ColeP., BrawnJ.: Etiology of human breast cancer.J. Natl. Cancer Inst., 50: 21–47, 1973.
11.
MalarkeyW.B., SchoredonI.L., StevensV.C., JamesA.C., LaneseR.R.: Twenty-four-hour preoperative endocrine profiles in women with benign and malignant breast disease.Cancer Res., 37: 4655–4659, 1977.
12.
MeitesJ.: Neuroendocrinology of lactation.J. Invest. Dermatol., 63: 119–124, 1974.
13.
MooreJ.W., ClarkG.M., BulbrookR.D., HaywardJ.L., MuraiJ.T., HammondG.L., SlireriP.K.: Serum concentrations of total and non-protein-bound estradiol in patients with breast cancer in normal controls.Int. J. Cancer, 15: 17–21, 1982.
14.
MuhlockO.: Role of hormones in the etiology of breast cancer.J. Natl. Cancer Inst., 48: 1213–1216, 1972.
15.
NadiaS.: Endocrine control of mammary gland development and function in the C3H/He Crgl mouse.J. Natl. Cancer Inst., 21: 1039–1063, 1958.
16.
SeidmanH., SilverbergE., HolebA.I.: Cancer statistics: A comparison of white and black populations.Cancer, 26: 2–4, 1976.
17.
WangD.Y., SwainM.C.: Hormones and breast cancer. In: Biochemistry of Women: Methods of Clinical Investigation, pp. 191–217, CurryA.S., and HewitlJ.V. (eds.), CRC Press, Boca Raton, 1974.
