One hundred patients with chronic lymphocytic leukemia (CLL) followed in our department between November 1969 and December 1982 were reviewed and classified according to the staging system proposed by the International Workshop on CLL (IWCLL). Analysis of actuarial survival curves revealed a significant chisquare value for heterogeneity and trend. In addition, thrombocytopenia and anemia appeared to be the most important risk factors. A large variability in the course of disease, not well explained by the staging system of the IWCLL, was found among the nonanemic and nonthrombopenic patients. Analysis of A and B stage patients according to absolute peripheral blood lymphocytosis (less or more than 50 × 109/liter) showed two separate patterns of survival.
BinetJ.L., LeporrierM., DighieroG., CharronD., D'AthisP., VaugierG., Merle BeralH., NataliJ.C., RaphaelM., NizetB., FollezouJ.Y.: A clinical staging system for chronic lymphocytic leukemia.Cancer, 40: 855–864, 1977.
3.
BinetJ.L., AuquierA., DighieroG., ChastangC., PiquetH., GoasguenJ., VaugierG., PotronG., ColonaP., OberlingF., ThomasM., TcherniaG., JacquillatC., BoivinP., LestyC., DuaultM.T., MonconduitM., BelabbesS., GremyF.: A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.Cancer, 48: 198–206, 1981.
4.
ChandraP., SawitskyA., ChananaD., ChikkappaG., CohnS.H., RaiK.R., CronkiteE.P.: Correlation of total body potassium and leukemic cell mass in the patients with chronic lymphocytic leukemia.Blood, 53: 594–603, 1979.
5.
Chronic Leukemia-Myeloma Task Force: Proposed guidelines for protocol studies. III. Chronic leukemia.Cancer Chemoter. Rep., 4: 159–165, 1973.
6.
MontserratE., MoreyM., RozmanC., FeliuE., GranenaA., Hernandez NietoL., NomdedeuB.: Interès de la clasificacion por estadios de la leucemia linfoide cronica.Sangre, 22: 901–911, 1977.
7.
MontserratE., RozmanC.: Subclassification of stage II chronic lymphocytic leukemia with prognostic and therapeutic implications.Lancet, 2: 854, 1979.
8.
PetoR., PikeM.C., ArmitageP., BreslowN.E., CoxD.R., HowardS.V., MantelN., McPhersonK., PetoJ., SmithP.G.: Design and analysis of randomized clinical trials requiring prolonged observation of each patient.II. Analysis and examples. Br. J. Cancer, 35: 1–39, 1977.
9.
PhillipsE.A., KempinS., PasseS., MikeW., ClarksonB.: Prognostic factors in chronic lymphocytic leukemia and their implications for therapy.Clin. Haematol., 6: 203–222, 1977.
10.
PujalJ., PavlovskyS., PavlovskyA.: Evaluation de une nueva clasificacion por estadios de la leucemia linfoide cronica.Sangre, 22: 43–50, 1977.
Report from international workshop on CLL by the writing committee: BinetJ.L., CatowskyJ., ChandraP., DighieroG., MontserratE., RaiK.R., SawitskyA.: Chronic lymphocytic leukemia: a proposal for a revised prognostic staging system.Br. J. Haematol., 48: 365–367, 1981.
13.
RozmanC., MontserratE., FeliuE., GranenaA., MarinP., NomdedeuB., Vives CorronsJ.L.: Prognosis of chronic lymphocytic leukemia: A multivariate survival analysis of 150 cases.Blood, 59: 1001–1005, 1982.
