The immunologic reactivity of glycoprotein antigens extractable from individual, histologically different ovarian and uterine cancers was studied taking into account their relationship with carcinoembryonic antigen (CEA), nonspecific cross-reacting antigen (NCA), α-fetoprotein (AFP), and α-1-antichymotrypsin. All studies were performed using specific immune sera against perchloric acid (PCA) extracts of ovarian mucinous cystadenocarcinoma (anti-PCA-CaOm) and cervical squamous cell carcinoma (anti-PCA-CaCx), and antisera against the reference antigens mentioned above. A considerable antigenic heterogeneity and the existence of several immunologically related antigenic systems were found: 1) CEA-like antigens; 2) NCA-type antigens; 3) an antigen different from CEA and NCA present in ovarian mucinous adenocarcinomas and often cross-reacting, but not identical with respective antigens of uterine body and cervical carcinomas; 4) an antigen reacting with anti-α-1-antichymotrypsin serum; and 5) an antigen reacting with anti-AFP serum.
BhattacharyaM., ChatterjeeS.K., BarlowJ.J., FujiH.: Monoclonal antibodies recognizing tumor-associated antigen of human ovarian mucinous cystadenocarcinomas.Cancer Res., 42: 1650–1654, 1982.
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BurtinP., FlandrinG., FondanecheM.C.: Presence of NCA (non-specific cross-reacting antigen) in the cells of the human granulocyte series.Blood Cells, 6: 263–273, 1980.
8.
BurtonR.M., HopeN.J., LubbersL.M.: A thermostable antigen associated with ovarian cancer.Am. J. Obstet. Gynecol., 125: 472–477, 1976.
9.
ChiangW.T., AlexanderE.R., KennyG.E.: Identification of a tumor-associated antigen in cervical carcinoma by two-dimensional (crossed) Immunoelectrophoresis.J. Natl. Cancer Inst., 58: 43–48, 1977.
10.
GaffarS.A., PrincierG.L., McIntireK.R., BraatzJ.A.: A human lung tumor-associated antigen cross-reactive with α-1-antichymotrypsin.J. Biol. Chem., 255: 8334–8339, 1980.
11.
GallS.A., WallingJ., PearlJ.: Demonstration of tumor-associated antigens in human gynecologic malignancies.Am. J. Obstet. Gynecol., 115: 387–393, 1973.
12.
HainesH.G., McCoyJ.P., HofheinzD.E., NgA.B.P., NordquistS.R.B., LeifR.C.: Cervical carcinoma antigens in the diagnosis of human squamous cell carcinoma of the cervix.J. Natl. Cancer Inst., 66: 465–474, 1981.
13.
HarlozinskaA., LisowskaE., RichterR., AlbertW., GawlikowskiW., DomagalaJ.: Immunological reactivity of glycoprotein antigens from human lung cancers.Neoplasma, 27: 641–652, 1980.
14.
HarlozinskaA., RichterR., AlbertZ., ZawadzkaH.: Antigenic heterogeneity of human lung cancers.J. Natl. Cancer Inst., 70: 427–433, 1983.
15.
HeumannD., CandardjisPh., CarrelS., MachJ.P.: Identification of the normal glycoprotein (NGP) crossreacting with CEA as a differentiation antigen of myeloid cells and macrophages. In: Carcinoembryonic Proteins.LehmannF.G. (Ed.), Vol. 2, pp. 3–13. Elsevier, North-Holland Biomedical Press, Amsterdam, 1979.
16.
IbrahimA.N., RobinsonR.A., MarrL., AbdelalA.T.H., NahmiasA.J.: Tumor-associated antigens in cervical cancer tissues and in sera from patients with cervical cancer or with head and neck cancer.J. Natl. Cancer Inst., 63: 319–323, 1979.
17.
ImamuraN., TakahashiT., LloydK.O., LewisJ.L.Jr., OldL.J.: Analysis of human ovarian tumor antigens using heterologous antisera: detection of new antigenic systems.Int. J. Cancer, 21: 570–577, 1978.
18.
Krop-WatorekA., SedlaczekP., LisowskaE.: The subunit structure of non-specific cross-reacting antigen (NCA).Molec. Immunol., 20: 777–785, 1983.
19.
KulaJ., HarlozinskaA., RichterR., AlbertZ., SwardJ., GawlikowskiW.: Carcinoembryonic antigen in gynecological cancers.Immunohistochemical localization and serum levels. Tumori, 69: 23–30, 1983.
Norgaard-PedersenB.: Tumour markers in germ cell tumours of gonadal and extragonadal origin. In: Clinical Application of Carcinoembryonic Antigen Assay.KrebsB.P., LaianneC.M., SchneiderM. (Eds.), pp. 325–337. Excerpta Medica, Amsterdam-Oxford, 1978.
22.
RaghavanD., NevilleA.M.: The use of tumour markers in the management of ovarian malignancy. In: Tumour Markers: Impact and Prospects.BoelsmaE., RiimkePh. (Eds.), Vol. 2, pp. 289–296. Elsevier, North-Holland, Biomedical Press, Amsterdam-New York-Oxford, 1979.
23.
WeekeB.: Crossed immunoelectrophoresis. In: A Manual of Quantitative Immunoelectrophoresis.AxelsenN.H., KrollJ., WeekeB. (Eds.), pp. 47–56. Blackwell Scientific Publications, Oxford, 1977.
24.
ZawadzkaH., LisowskaE., HarlozinskaA., AlbertZ., RichterR., JanuszM.: Differences in the purification effect of carcinoembryonic antigen (CEA) from the three different hepatic metastases of rectum carcinoma.Neoplasma, 26: 157–167, 1979.
