Effect of local tumor hyperthermia (42 °C) at various intervals ranging from 1 to S h and in combination with antineoplastic drugs was investigated on P388 murine lymphocytic leukemic cells by using an in vitro-in vivo bioassay method. It was observed that a 1-h exposure resulted in a one log cell kill. In combination studies with hyperthermia and anticancer drugs, 1-h exposure to hyperthermia along with 10 μg/ml in vitro concentration of adriamycin (NSC 23127), vincristine (NSC 67574), or 5-fluorouracil (NSC 19893) resulted in the synergistic cell killing action against P388 leukemic cells. However, cyclophosphamide (NSC 26271) and cytosine arabinoside (NSC 63878) did not show any enhanced therapeutic effect.
Get full access to this article
View all access options for this article.
References
1.
AbeM., HiraokaM., TakahoshiM., OnoK., NoharH.: Clinical experience with microwave and radiofrequency thermotherapy in the treatment of advance cancer.Natl. Cancer Inst., Monogr., 61: 411–414, 1982.
2.
AdwankarM.K., ChitnisM.P.: Alteration in natural resistance of sarcoma-180 cells to bouvardin (NSC 259968) following hyperthermia.Tumori, 69: 309–312, 1983.
3.
CaveliereR., CiocattoE.C., GiovanellaB.C., HeidelbergerC., JohnsonR.O., MargottiniM., MondovimB., MoriccaG., Rossi-FanelliA.: Selective heat sensitivity of cancer cells.Cancer, 20: 1351–1381, 1967.
4.
CrileG.Jr.: Selective destruction of cancers after exposure to heat.Ann. Surg., 156: 404–407, 1962.
5.
DahlO.: Interaction of hyperthermia and doxorubicin on a malignant, neurogenic rat cell line (BT4C) in culture.Natl. Cancer Inst., Monogr., 61: 251–253, 1982.
6.
DicksonJ.A., SuzangarM.: In vitro-in vivo studies on the susceptibility of solid Yoshida sarcoma to drugs and hyperthermia (42 °C).Cancer Res., 34: 1263–1273, 1974.
7.
DicksonJ.A.: The effect of hyperthermia in animal tumour systems. In: Selective Heat Sensitivity of Cancer Cells.Springer Verlag, Berlin, Heidelberg, New York, 1977.
8.
GeranR.I., GreenbergN.H., MacdonaldM.M., SchumacherA.M., AbbottB.J.: Protocols for screening chemical agents and natural products against animal tumours and other biological systems. Third edition. Cancer Chemother. Rep., 3: No. 2, 1972.
9.
GiovanellaB.C., LohmanW.A., HeidelbergerC.: Effect of elevated temperatures and drugs on the viability of L1210 leukemic cells.Cancer Res., 30: 1623–1631, 1970.
10.
HahnG.M., BraunJ.C., Harke-darI.: Thermotherapy: Synergism between hyperthermia (42-43 °C) and adriamycin (or bleomycin) in mammalian cell inactivation.Proc. Natl. Acad. Sci. USA, 72: 937–940, 1975.
11.
HahnG.M., LiG.C.: Interactions of hyperthermia and drugs.Treatments and probes. Natl. Cancer Inst., Monogr., 61: 317–323, 1982.
12.
HallR.R., SchadeR.O.K., SwineeyJ.: Effects of hyperthermia on bladder cancer.Br. Med. J., 2: 593–594, 1974.
13.
MarmoraJ.B., PoundsD., HahnG.M.: Clinical studies with ultrasound for the induction of local hyperthermia.Natl. Cancer Inst. Monogr., 61: 333–337, 1982.
14.
MondoviB., StormR., RotillioG., Finazzi-AgroA., CaveliereR., Rossi-FanelliA.: Biochemical mechanism of selective sensitivity of cancer cells.I: Studies on cellular respiration. Eur. J. Cancer, 5: 129–136, 1969.
15.
MuckleD.S., DicksonJ.A.: Selective inhibitory effect of hyperthermia on metabolism and growth of malignant cells.Br. J. Cancer, 25: 771–778, 1971.
16.
MuckleD.S., DicksonJ.A.: Hyptrthermia (42 °C) as an adjuvant to radiotherapy and chemotherapy in the treatment of the allogenic VX2 carcinoma in rabbit.Br. J. Cancer, 27: 307–315, 1973.
17.
NeumanH., FabriciusH.A., EngelhardtR.: Moderate whole body hyperthermia in combination with chemotherapy in the treatment of small cell carcinoma of the lung.A pilot study. Natl. Cancer Int. Monogr., 61: 427–429, 1982.
18.
StormR., Sciescia-SantoraA., CriffoC., BozziA., MondoviB., Rossi-FanelliA.: The biochemical mechanism of selective heat sensitivity of cancer cells.IV. Inhibition of RNA synthesis. Eur. J. Cancer, 9: 103–112, 1973.
19.
StormR., CaiafaP., MondoviB., Rossi-FanelliA.: Temperature dependence of transcellular migration of glutamate in normal and malignant cells. In: Permeability and Function of Biological Membranes.North Holland Press, Amsterdam, 1970.
