Forty-nine patients with previously untreated advanced Hodgkin's disease were treated in our Institution between 1973 and 1981. Treatment modalities of these patients were reviewed, and they were divided into 3 groups according to the treatment employed: 13 patients received MOPP only, 22 patients received MOPP plus involved field radiotherapy, and 14 received alternating MOPP/ABVD chemotherapy. The response rates for the 3 groups were respectively 38.5%, 63.6% and 78.6%. A longer follow-up is needed to assess a significant difference in survival curves. The advantages of adjuvant radiotherapy and alternating non-cross-resistant drugs in advanced Hodgkin's disease are discussed.
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References
1.
BergsagelD.E., BascoV.E., BuschR., GilliesJ., IsraelsR., WhitelawM., MillerA.B.: Trials of MOPP alone versus MOPP and radiotherapy for advanced Hodgkin's disease.Proc. Am. Soc. Clin. Oncol., 21: 464, 1980.
2.
BloomfieldC.D., WeissR.B., FortunyI., VosikaG., KennedyB.J.: Combination chemotherapy with cyclophosphamide, vinblastine, procarbazine and prednisone (CVPP) for patients with advanced Hodgkin's disease. An alternative program to MOPP.Cancer, 38: 42–48, 1976.
3.
BloomfieldC.D., PajakT.F., GlicksmanA.S., GottliebA.J., ColemanM., NissenN.I., RaflaS., StutzmanL., VinciguerraV., GlidewellO.J., HollandJ.F.: Chemotherapy and combined modality therapy for Hodgkin's disease: A progress report on cancer and leukemia group B studies.Cancer Treat. Rep., 66: 835–846, 1982.
4.
BonadonnaG., ZucaliR., MonfardiniS., De LenaM., UslenghiC.: Combination chemotherapy of Hodgkin's disease with adriamycin, bleomycin, vinblastine and imidazole carboxamide versus MOPP.Cancer, 36: 252–259, 1975.
5.
BonadonnaG., FossatiV., De LenaM.: MOPP versus MOPP plus ABVD in stage IV Hodgkn's disease.Proc. AACR-ASCO, 19: 363 abstract, 1978.
6.
ChisesiT., RicciardiO., Dal FiorS., CappellariF., PozzaF., DiniE.: Treatment of early stage Hodgkin's disease with radiation therapy plus short-cycle (3 MOPP) adjuvant chemotherapy.Tumori, 5: 455–461, 1983.
7.
De VitaV.T., SerpickA.A.: Combination chemotherapy in the treatment of advanced Hodgkin's disease.Proc. Am. Ass. Cancer Res., 8–13, 1967.
8.
GamsR.A., DurantJ.R., BartolucciA.A.: Chemotherapy for advanced Hodgkin's disease: Conclusions from the Southeastern Cancer Study Group.Cancer Treat. Rep., 66: 899–905, 1982.
9.
GlickJ.H., BarnesJ.M., BakemeierR.F., ProsnitzL.R., BennettJ.M., NeimanR.S., CostelloW., OrlowE.L.: Treatment of advanced Hodgkin's disease: 10-year experience in the Eastern Cooperative Oncology Group.Cancer Treat. Rep., 66: 855–870, 1982.
LeviJ.A., WiernikP.H., DiggsC.H.: Combination chemotherapy of advanced previously treated Hodgkin's disease with streptozotocin, CCNU, adriamycin and bleomycin.Med. Pediat. Oncol., 3: 33–40, 1977.
14.
MorgenfeldM.C., PavlovskyA., SuarezA., SomozaN., PavlovskyS., PalauM., BarrosC.A.: Combined cyclophosphamide, vincristine, procarbazine and prednisone therapy of malignant lymphoma. Evaluation of 190 patients.Cancer, 36: 1241–1249, 1976.
15.
MorgenfeldM.C., SomozaN., MagnascoJ., PavlovskyS., De BonesanaA.C., BezaresR., SuàrezA., PileggiJ., LeinJ.M., MacchiA., CalabriaS.I., GarayG.E., De SicaS.C., BesuschioS.: Combined chemotherapy cyclophosphamide, vinblastine, procarbazine and prednisone (CVPP) versus CVPP plus CCNU (CCVPP) in Hodgkin's disease.Cancer, 43: 1579–1586, 1979.
16.
NissenN.I., PajakT.F., GlidewellO.: A comparative study of a BCNU-containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease.Cancer Treat. Rep., 66: 871–879, 1982.
17.
ProsnitzL.R., FarberL.R., FischerJ.J., BertinoJ.R., FischerD.B.: Long-term remissions with combined modality therapy for advanced Hodgkin's disease.Cancer, 37: 2826–2833, 1976.
SantoroA., BonadonnaG., BonfanteV., ValagussaP.: Alternating drug combinations in the treatment of advanced Hodgkin's disease.N. Engl. J. Med., 306: 770–775, 1982.
20.
YoungC.W., StrausD.J., MyersJ., PasseS., NisceL.Z., LeeB.J., KozinerB., ArlinZ., KempinS., GeeT., ClarksonB.D.: Multidisciplinary treatment of advanced Hodgkin's disease by an alternating chemotherapeutic regimen of MOPP/ABDV and low-dose radiation therapy restricted to originally bulky disease.Cancer Treat. Rep., 66: 907–914, 1982.
