Continuous administration of 500 ppm hexachlorocyclohexane (HCH) in the diet induced 100 % liver tumors in mice, but none were observed in rats and hamsters treated with the same dose of HCH. In Swiss male mice, tumor incidence at earlier ages was greater than that observed in corresponding age groups of Swiss female mice. It was further observed that in Swiss females, sex hormones retarded the tumorigenic effect of HCH; in BALB/c mice a similar phenomenon was not observed.
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References
1.
BatesR.R.: Sex hormones and skin tumorigenesis. I. Effect of estrous cycle and castration on tumorigenesis by 7,12-dimethylbenz(a)anthracene.J. Natl. Cancer Inst., 41: 559–563, 1968.
2.
FurukawaH., IwangaT., KoyamaH., TaniguchiH.: Effect of sex hormones on carcinogenesis in the stomachs of rats.Cancer Res., 42: 5181–5182, 1982.
3.
GrassoP., CramptonR., HoosanJ.: The mouse and carcinogenesis testing, Surrey, England.The British Industrial Biological Res. Association, 1979.
4.
IrvingC.C.: Comparative toxicity of N-hydroxy-2-acetylaminofluorene in several strains of rats.Cancer Res., 35: 2959–2961, 1975.
5.
ItoN., HanahouchiM., SugimaraS., ShiraiT., FukshimaS., NagasakiH.: Reversibility and irreversibility of liver tumor in mice induced by α-isomer of 1,2,3,4,5,6-hexachlorocyclohexane.Cancer Res., 36: 2227–2234, 1976.
6.
NagasakiH., MarugamiM., TomiS., MegaT., ItoN.: Development of hepatoma in mice treated with benzene hexachloride.Gann, 62: 431, 1971.
7.
NewberneP.M., McConnellR.G.: Toxicological pathology: Issues and uncertainities. In: GalliC.L., MurphyS.D., and PaolettiR. (eds.). The Principles and Methods in Modern Toxicology, pp. 223–258, Elsevier Press, New York, 1980.
8.
NigamS.K., BhattD.K., KarnikA.B., ThakoreK.N., Arvind BabuK., LakkadB.C., KashyapS.K., ChatterjeeS.K.: Experimental studies on insecticides commonly used in India.J. Cancer Res. Clin. Oncol., 99: 143–152, 1981.
9.
RanadiveK.J.: Diet formula evolved at the Indian Cancer Research Centre, L.A.C.Collected papers, 5: 39–41, 1957.
10.
Schulte-HermannR., ParzefallW.: Failure to discriminate initiation from promotion of liver tumours in a long-term study with the phenobarbitaltype inducer α-hexachlorocyclohexane and the role of sustained stimulation of hepatic growth and monooxygenases.Cancer Res., 41: 4140–4146, 1981.
11.
ShahinM.M., Von BorstelR.C.: Mutagenic and lethal effects of α-benzene hexachloride, dibutyl phthalate and trichloroethylene in Saccharomyces cerevisae. Mutat.Res., 48: 173–178, 1977.
12.
ShirasuY., MoriyaM., KotoK., FurnhashiA., KadaT.: Mutagenicity screening of pesticides in the microbial system.Mutat. Res., 40: 19–30, 1976.
13.
TennekesH.S., WrightA., DixK.: The effects of dieldrin, diet and other environmental components on enzyme function and tumor incidence in livers of CF-1 mice.Arch. Toxicol, 2(suppl.): 197–212, 1979.
14.
WilliamsG.M.: Liver carcinogenesis: The role for some chemicals of an epigenetic mechanism of liver tumor promotion involving modification of cell membrane.Food Cosmet. Toxicol., 19: 577–583, 1981.
15.
WilliamsG.M., TelangS., TongC.: Inhibition of intercellular communication between liver cells by the liver tumor promoter 1,1,1-trichloro 2,2-bis-(p-chlorophenyl)ethane.Cancer Lett., 11: 339–344, 1981.
