A case of familial testicular malignancy in a father and his son is reported. This represents the seventh described case of father-son testicular cancer. The father had seminoma and the son had teratocarcinoma. Both patients’ peripheral blood lymphocytes were tested for 52 HLA specificities: the father's antigens were HLA A3, B13, B14, Cw6, Cw8 and the son's were HLA A2, A3, B14, Cw8. (Common haplotype: A3, B14, Cw8). The association between HLA antigens and testicular cancer is discussed.
Get full access to this article
View all access options for this article.
References
1.
ArcadiJ.A.: Testicular neoplasms in father and son.J. Urol., 110: 306, 1973.
FatterlyJ.C.: Malignant tumors in father and son.Can. Med. Assoc. J., 113: 92, 1975.
4.
FraleyE.E., LangeP.H., KennedyB.J.: Germ-cell testicular cancer in adults (I).N. Engl. J. Med., 301: 1370–1377, 1979.
5.
IlleniM.T., RoviniD.: Il sistema HLA nell'uomo.Argomenti di oncologia, 2: 115–135, 1981.
6.
LapesM., IozziL., ZiegenfusW.D., AntoniadesK., VivacquaR.: Familial testicular cancer in a father (bilateral seminoma-embryonal cell carcinoma) and son (teratocarcinoma).A case report and review of the literature. Cancer, 39: 2317–2320, 1977.
7.
MajskyA., AbrahamovaJ., KorinkovaP., BekV.: HLA system and testicular germinative tumors.Oncology, 36: 228–230, 1979.
8.
MusaM.B.: Germ-cell malignant tumors in father and son.Can. Med. Assoc. J., 112: 1201–1202, 1975.
SilberS.J., CittanS., FriedlanderG.: Testicular neoplasm in father and son.J. Urol., 108: 889, 1972.
11.
TerasakiP.I., PerdueS.T., MickeyM.R.: HLA frequencies in cancer. A second study. In: pp 321–328, MulvihillT.J., MillerR.W., FraumeniJ.F. (Eds.), Genetics of Human Cancer, Vol. 3, Raven Press, New York, 1977.
