The antitumoral activity of some octahedral platinum(IV) and square-planar platinum(Ii) derivatives against Yoshida ascites tumor in the rat is reported. It is shown that only those octahedral platinum(IV) complexes which give active reduction products are active. These results support the hypothesis that the antitumor activity of octahedral complexes involves activation by in vivo reduction. Anticancer drugs functioning by this mechanism may be preferentially toxic to or may localize in hypoxic areas of tumors.
Get full access to this article
View all access options for this article.
References
1.
ButourJ.L., MacquetJ.P.: Differentiation of DNA-platinum complexes by fluorescence.Eur. J. Biochem., 78: 455–463, 1977.
2.
ButourJ.L., MacquetJ.P.: Platinum determination in DNA-platinum complexes by fluorescence spectrophotometry.Anal. Biochem., 89: 22–30, 1978.
3.
ClarkeM.J., BitlerS., RennertD., BuchbinderM., KelmanA.D.: Reduction and subsequent binding of ruthenium ions catalyzed by subcellular components.Inorg. Biochem., 12: 79–87, 1980.
4.
CleareM.J.: Transitional metal complexes in cancer chemotherapy.Coor. Chem. Rev., 12: 349–405, 1974.
5.
CramerR.E., DahlstromP.L., SenM.J.T., NortonT., KashiwagiM.: Crystal and molecular structure of cis-Pt(NH3)2(Guo)2Cl3/2(ClO4)1/2]7H2O and anticancer activity of cis-[Pt(NH3)2(Puo)2]Cl2 complexes.Inorg. Chem., 19: 148–154, 1980.
6.
DennistonM.L., SternsonL.A., ReptaA.J.: Analysis of total platinum derived from cisplatin in tissue. Anal.Lett., 14(B6): 451–462, 1981.
7.
GrinbergA.A.: An introduction to the chemistry of complex compounds. Ed. by BuschD.H., and TrimbleR.F., p. 253, Pergamon Press, Oxford, 1962.
8.
GruberJ.E., JennetteK.W.: Metabolism of the carcinogen Chromate by rat liver microsomes.Biochem. Biophys. Res. Commun., 82: 700–706, 1978.
KauffmanG.B., CowanD.O.: Cis- and trans-dichlo-rodiammineplatinum(II).Inorg. Synth., 7: 239–241, 1973.
11.
KelmanA.D., BuchbinderM.: Platinum-DNA crosslinking: Platinum antitumor drug interaction with native lambda bacteriophage DNA studied using a restriction endonuclease.Biochimie, 60: 893–899, 1978.
12.
LongD.F., PattonT.F., ReptaA.J.: Platinum levels in human erythrocytes following intravenous administration of cisplatin: Importance of erythrocytes as a distribution site for platinum species.Biopharm. Drug Disp., 2: 137–146, 1981.
MannF.G.: The constitution of complexes metallic salts.Part II. The platinum derivatives of ββ'-diaminodiethylamine. J. Am. Chem. Soc., 56: 466–474, 1934.
21.
MetzlerD.E.: Biochemistry, Academic Press, New York, 488–588, 1977.
22.
MillardM.M., MacquetJ.P., TheophanidesT.: X-ray photoelectron spectroscopy of DNA-Pt complexes.Evidence of O6(Gua)-N7(Gua) chelation of DNA with cis-dichlorodiamineplatinum(II). Biochim. Biophys. Acta, 402: 166–170, 1975.
23.
PendyalaL., CowensJ.W., CreavenP.J.: Studies on the pharmacokinetics and metabolism of cis-dichloro-trans-dihydroxy-bis-isopropylamine platinum(IV) in the dog.Cancer Treat. Rep., 66: 509–516, 1982.
24.
RosenbergB.: Platinum complex-DNA interactions and anticancer activity.Biochimie, 60: 859–867, 1978.
25.
RosenbergB., Van CampL.: The successfull regression of large solid sarcoma 180 tumors by platinum compounds.Cancer Res., 30: 1799–1802, 1970.
26.
RosenbergB., Van CampL., TroskoJ.E., MansourV.H.: Platinum compounds: A new class of potent antitumor agents.Nature, 222: 385–386, 1969.
27.
ScottacasaG.L., KuylenstiernaB., ErnsterL., BergstrandA.: An electrontransport system associated with the outer membrane of liver mitochondria.A biochemical and morphological study. J. Cell Biol., 32: 415–438, 1967.
28.
SrivastavaR.C., FroehlichT., EichhornG.L.: The effect of platinum binding on the structure of DNA and its function in RNA synthesis.Biochimie, 60: 879–891, 1978.
29.
VaupelP.: Hypoxia in neoplastic tissues.Microvascular Res., 13: 399–408, 1977.
