The morphologic patterns of mammary tumors induced by milk-transmitted C3H and RIII murine mammary tumor viruses (MuMTVs) in BALB/c hosts infected by foster nursing were investigated further and compared taking into account several tumor and host variables. Comparison of BALB/cfC3H and BALB/cfRIII mammary tumors under identical tumor and host conditions showed highly significant differences in subgross morphology and histologic structure. Differences in cytology were also observed. Data suggest that mammary tumor morphology in high cancer strain mice is controlled by the causative MuMTV.
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References
1.
DunnT.B.: Morphology of mammary tumors in mice.In: The Physiopathology of Cancer, 2nd ed., pp. 38–84, HomburgerF. ed., Hoeber, New York, 1958.
2.
Van Ebbenhorst TengbergenW.J.P.R.: Morphological classification of mammary tumours in the mouse.Pathol. Eur., 5: 260–272, 1970.
3.
HestonW.E.VlahakisG.: Mammary tumors, plaques and hyperplastic alveolar nodules in various combinations of mouse inbred strains and the different lines of the mammary tumor virus.Int. J. Cancer, 7: 141–148, 1971.
4.
OliviM.SquartiniF.RossiG.: Sulla morfologia dei tumori mammari da metilcolantrene in topi BALB/c privi dell'agente.Lav. Ist. Anat. Istol. Patol. Perugia, 23: 167–201, 1963.
5.
PingitoreR.: Stability of characters of mammary tumors in BALB/cfRIII mice.Tumori, 66: 439–444, 1980.
6.
SquartiniF.: Strain differences in growth of mouse mammary tumors.J. Natl. Cancer Inst., 26: 813–828, 1961.
7.
SquartiniF.: Responsiveness and progression of mammary tumors in high-ancer-strain mice.J. Natl. Cancer Inst., 28: 911–926, 1962.
8.
SquartiniF.: Tumours of the mammary gland.In: Pathology of tumours in laboratory animals. Vol. II. Tumour sof the mouse, pp. 43–90. TurusovV.S. ed., I.A.R.C., Lyon, 1979.
9.
SquartiniF.BistocchiM.BuongiornoL.: Development, morphology and progression of mammary tumors during and after fertile life in BALB/cfRIII mice.J. Natl. Cancer Inst., 66: 311–319, 1981.
10.
SquartiniF.BolisG.B.RossiG.: BALB/cfRIII: A new high mammary tumor and high leukemia mouse strain.J. Natl. Cancer Inst., 52: 1635–1641, 1974.
11.
SquartiniF.BucciarelliE.BolisG.B.: Presence and transmission of mammary tumor virus and leukemia virus in the BALB/cfRIII mouse.J. Natl. Cancer Inst., 53: 137–150, 1974.
12.
SquartiniF.PingitoreR.BistocchiM.: Characterization of RIII mouse mammary tumor virus.In: Breast acncer: new concepts in etiology and control, pp. 213–223. BrennanM.J.McGrathC.M.RichM.A. eds., Academic Press, New York, 1980.
13.
SquartiniE.RossiG.PaolettiI.: Characters of mammary tumours in BALB/c female mice foster-nursed by C3H and RIII mothers.Nature, 197: 505–506, 1963.
14.
SquartiniE.SeveriL.: Strain differences in the mammary tumor-inducing virus as detected by the characters and behavi our of neoplasms.In: Ciba Foundation symposium on tumour viruses of murine origin, pp. 82–103. WolstenholmeG.E.W.O'ConnorM. eds., J. and A. Churchill Ltd., London, 1962.
