The invasive properties of 2 types of breast cancers were tested on an « in vivo » model system in which 9-day-old chorioallantoic membrane (CAM) of chick embryo was used. Similar to HeLa and ALL cells, the breast « negative » cells invaded the blood vessels of the host, whereas the breast « positive » cells were seen in the mesoderm away from blood vessels of the host. This finding probably explains the intrinsic aggressive property of breast « negative » cells.
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References
1.
BorahV.J., ShahP.N., GhoshS.N., SampatM.B., JussawallaD.J.: Further studies on the prognostic importance of Barr body frequency in human breast cancer: With discussion on its probable mechanism. J. Surg. Oncol., 13: 1–7, 1980.
2.
EastyD.M., EastyG.C.: Measurement of the ability of cells to infiltrate normal tissues in vitro. Br. J. Cancer, 29: 36–49, 1974.
3.
GhoshS.N., ShahP.N.: Prognosis and incidence of sex chromatin in breast cancer. A preliminary report. Acta Cytol., 19: 58–61, 1975.
4.
HartI.R.: The selection and characterization of an invasive variant of the B16 melanoma. Am. J. Pathol., 97: 587–600, 1979.
5.
ReadeP.C., JenkinC.R., TurnerK.J.: The synthesis by foetal chicks and rats of serum proteins having some properties of the immunoglobulins. Australian J. Exp. Biol. Med. Sci., 43: 699–712, 1965.
6.
ScherC.D., HaudenschildC., KlagsbrunM.: The chick chorioallantoic membrane as a model system for the study of tissue invasion by viral transformed cells. Cell, 8: 373–382, 1976.
7.
SchleichA.B., FrickM., MayerA.: Patterns of invasive growth in vitro. Human decidua graviditatis confronted with established human cell lines and primary human explants. J. Natl. Cancer Inst., 56: 221–237, 1976.
8.
SeshadriR., GhoshS.N., ShahP.N., BorahV.J.: Barr body frequency in the human breast cancer tissues. A prospective study on its prognostic value and its correlation with specific eostradiol receptors. Eur. J. Cancer, 13: 99–102, 1977.
9.
TickleC., CrawleyA., GoodmanM.: Cell movement and the mechanism of invasiveness: A survey of the behaviour of some normal and malignant cells implanted into the developing chick wing bud. J. Cell. Sci., 31: 293–322, 1978.
