To define the frequency of gastric epithelial dysplasia (precancerous lesion), 1463 biopsies from 842 endoscopically studied patients were reassessed. Mild dysplasia was found in 19.9 % of the cases, moderate in 4.1 %, severe in 0.95 %. Since the clinical and biological significance of the lesion is still an open question, indications for follow-up are discussed in the light of personal views, together with a critical evaluation of the recently proposed classifications.
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References
1.
CuelloC., CorreaP.: Dysplastic changes in intestinal metaplasia of the gastric mucosa. In: Gastric Cancer, HerfarthCh., and SchlagP. Eds., pp. 83–90, Springer-Verlag, Berlin, 1979.
2.
GrundmannE.: Histologic types and possible initial stages in early gastric carcinoma.Beitr. Pathol., 154: 256–280, 1975.
3.
GrundmannE., SchlakeW.: Histology of possible precancerous stages in the stomach. In: Gastric Cancer, HerfarthCh., and SchlagP. Eds., pp. 72–82, Springer-Verlag, Berlin, 1979.
4.
MeisterH., HolubarschCh., HaferkampO., SchlagP., HerfarthCh.: Significance and location of atrophic gastritis and of glandular dysplasia in benign and malignant gastric disease. In: Gastric Cancer, HerfarthCh., and SchlagP. Eds., pp. 105–107, Springer-Verlag, Berlin, 1979.
5.
MingS.G.: Gastric carcinoma: A pathobiological classification.Cancer, 39: 2475–2485, 1977.
6.
MorsonB.C., SobinL.H., GrundmannE., JohansenA., NagayoT., Serck-HanssenA.: Precancerous conditions and epithelial dysplasia in the stomach.J. Clin. Pathol., 33: 711–721, 1980.
7.
MurakamiT.: Early Gastric Cancer.MurakamiT. Ed., Tokyo, University of Tokyo Press, 1971.
8.
NagayoT.: Histological diagnosis of biopsied gastric mucosae with special reference to that of borderline lesions.Gan. Monogr. Cancer Res., 11: 245–256, 1971.
9.
NagayoT.: Precursors of human gastric cancer: Their frequencies and histological characteristics. In: Pathophysiology of Carcinogenesis in Digestive Organs.FaberE. Eds., pp. 151–161, University of Tokyo Press, Tokyo Univ. Park Press, Baltimore, 1977.
10.
OehlertW., KellerP., HenkeM., StrauchM.: Die Dysplasien der Magenschleimhaut.Das Problem ihrer klinischen Bedeutung. Dtsch. Med. Wochenschr., 100: 1950–1956, 1975.
11.
OehlertW.: Biological significance of dysplasias of the epithelium and of atrophic gastritis. In: Gastric Cancer, HerfarthCh., and SchlagP. Eds., pp. 91–104, Springer-Verlag, Berlin, 1979.
12.
OrlandiF., FreddaraU., KochM.M., AlbanoO., BianchiP., ChiandussiL., ColtortiM., DobrillaG., FrezzaM., GasbarriniG., GentiliniP., ManciniA.M., ManentiF., NaccaratoR., PagliaroL., PisiE., BianchiF., TisonV., VermeG.: Observer error in morphological diagnosis of chronic active hepatitis and cirrhosis.Ital. J. Gastroenterol., 11: 5–8, 1979.
13.
StockbruggerR.W., MenonG.G., BeilbyJ.O.W., BourneR., MasonR., CottonP.B.: Endoscopic screening in patients with pernicious anaemia. Abstracts of the IV European Congress of Gastro-intestinal Endoscopy, Hamburg, June 13–14, 1980, p. 17, Georg Thieme Verlag, Stuttgart-New York, 1980.
14.
TeglbjaergP.S., NielsenH.O.: «Small intestinal type » and « colonic type » intestinal metaplasia of the human stomach.Acta Pathol. Microbiol. Scand. Sect A, 86: 351–355, 1978.
15.
WhiteheadR., TrueloveS.C., GearM.W.: The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens.J. Clin. Pathol., 25: 1–11, 1972.
16.
WhiteheadR.: Mucosal biopsy of the gastrointestinal tract. pp. 7–32, W.B. Saunders Company Ltd., London, 1973.
17.
World Health Organization: Report of a WHO meeting on the histological definition of precancerous lesions.Geneva, WHO, 1972.