Four cases of infantile sarcomatous renal tumors are reported. Rhabdomyoblastic differentiation was investigated in these tumors by the immunoperoxidase method using antimyoglobin sera. Rhabdomyoblastic cells were found in 2 cases and in a metastasis of one case in which the primary tumor was composed by undifferentiated cells negative for myoglobin stain. The histogenesis of these neoplasias is discussed, and it is suggested that they are a sarcomatous variant of Wilms’ tumor.
Get full access to this article
View all access options for this article.
References
1.
BannayanG.A., HuvosA.G., D'AngioG.J.: Effect of irradiation on the maturation of Wilms’ tumor.Cancer, 27: 812–818, 1971.
2.
BeckwithJ.B., PalmerN.F.: Histopathology and prognosis of Wilms’ tumor.Cancer, 41: 1937–1948, 1978.
3.
BenningtonJ.L., BeckwithJ.B.: Tumors of the kidney, renal pelvis and ureter. Second Series, fascicle 12, Atlas of Tumor Pathology, Armed Force Institute of Pathology, Washington D.C., p. 66, 1975.
D'AngioG.J., EvansA.F., BreslowM., BeckwithB., BishopH., FeiglP., GoodwinW., LeadeL.L., SinksL.F., SutowW., TefftM., WolffJ.: The treatment of Wilms’ tumor: Results of the National Wilms’ Tumor Study.Cancer, 38: 633–646, 1976.
6.
De ChadarévianJ.P., FletcherB.D., ChattenJ., RabinovitchH.H.: Massive infantile nephroblastomatosis: A clinical, radiological and pathological analysis of four cases.Cancer, 39: 2294–2305, 1977.
7.
JerebB., SandstedB.: Structure and size versus prognosis in nephroblastoma.Cancer, 31: 1473–1481, 1973.
8.
JoshiV.V., BanerjeeA.K., YadavK., PathakI.C.: Cystic partially differentiated nephroblastoma: A.clinico-pathologic entity in the spectrum of infantile renal neoplasia. Cancer, 40: 789–795, 1977.
9.
KiddJ.M.: Exclusion of certain renal neoplasm from the category of Wilms’ tumor.Scientific Proceedings of the American Association of Pathology and Bacteriology. 67th Annual Meeting 1970. Am. J. Pathol., 59: 162, 1970.
10.
LemerleI., VouteP.A., TournadeM.F., DelamarreJ.F.M., JerebB., AnstromL., FlamantR., Gerard-MarchantR.: Preoperative versus postoperative radiotherapy, single versus multiple courses of actinomycin D, in the treatment of Wilms’ tumor: Preliminary results of a controlled clinical trial conducted by the International Society of Paediatric Oncology (S.I.O.P.).Cancer, 38: 647–654, 1976.
11.
MarsdenH.B., LawlerW., KumarP.M.: Bone metastasizing renal tumors of childhood.Cancer, 42: 1922–1928, 1978.
12.
MarsdenH.B., LawlerW.: Bone metastasizing renal tumor of childhood.Virchows Arch. [Pathol. Anat.], 387: 341–351, 1980.
13.
MorganE., KiddJ.: Undifferentiated sarcoma of the kidney: A tumor of childhood with histopathological and clinical characteristics distinct from Wilms’ tumor.Cancer, 42: 1916–1921, 1978.
14.
MukaiK., RosaiJ., HallawayB.E.: Localization of myoglobin in normal and neoplastic human skeletal muscle cells using an immunoperoxidase method.Am. J. Surg. Pathol., 3: 373–376, 1980.
15.
NovakR.W., CacesJ.N., WarrenW.S.: Sarcomatous renal tumor of childhood.An electron microscopic study. Am. J. Clin. Pathol., 73: 622–625, 1980.
16.
PenchanskyL., GalloG.: Rhabdomyosarcoma of the kidney in children.Cancer, 44: 285–292, 1979.
17.
PerezC.A., KaimanH.A., KeithI., MillW.B., ViettiT.J., PowersW.E.: Treatment of Wilms’ tumor and factors affecting prognosis.Cancer, 32: 609–617, 1973.
18.
SternbergerL.A.: Immunocytochemistry (2nd ed.). Wiley, New York, 1979.
19.
TremblayM.: Ultrastructure of a Wilms’ tumor and myogenesis.J. Pathol., 105: 269–277, 1971.