The clinical and pathologic features of 34 uterine sarcomas were studied to determine the natural history of the disease. Sixteen patients had leiomyosarcoma, five mixed mesodermal sarcoma, ten endometrial stromal sarcoma, two carcinosarcoma and one endolymphatic stromal myosis. The patients were treated without an unique protocol. At 3 years the actuarial relapse-free survival was 53.6 %: 68.4 % in stage I-II patients and 22.2 % in stage III-IV patients. As regards the histologic subtype mixed mesodermal sarcomas had the best prognosis; endometrial stromal sarcomas the worst. The necessity of a uniform clinical and histologic classification as well as the importance of controlled clinical trials are pointed out.
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References
1.
AaroL.A., SymmondsR.E., DockertyM.B.: Sarcoma of the uterus.A clinical and pathologic study of 177 cases. Am. J. Obstet. Gynecol., 94: 101–109, 1966.
2.
BadibA.O., VongtamaV., KuroharaS.S., WebsterJ.H.: Radiotherapy in the treatment of sarcomas of the corpus uteri.Cancer, 24: 724–729, 1969.
3.
BaggishM.S., WoodruffD.J.: Uterine stromatosis.Clinico-pathologic features and hormone dependancy. Obstet. Gynecol., 40: 487–489, 1972.
BoutselisJ.G., UlleryJ.C.: Sarcomas of the uterus.Obstet. Gynecol., 20: 23–25, 1962.
6.
ChristophersonW.M., WilliamsonE.O., GrayL. A.: Leiomyosarcoma of the uterus.Cancer, 29: 1512–1517, 1972.
7.
CorscadenJ.A., SingliB.P.: Leiomyosarcoma of the uterus.Am. J. Obstet Gynecol., 75: 149–155, 1958.
8.
Di SaiaP.J., MorrowP.C., BoronowR., CreasmanW., MittelstaedtL.: Endometrial sarcoma: lymphatic spread pattern.Am. J. Obstet. Gynecol., 130: 104–105, 1978.
9.
HartW.R., BillmanJ.K.: A reassessment of uterine neoplasm originally diagnosed as leiomyosarcomas.Cancer, 41: 1902–1910, 1978.
10.
HunterW.C., NohlgrenJ.E., LancefieldS.M.: Stromal endometriosis or endometrial sarcoma.A. re-evaluation of old and new cases with especial reference to duration, recurrences and metastases. Am. J. Obstet. Gynecol., 72: 1072–1088, 1956.
11.
HuynhT., GlassburnJ.R., BradyL.W.: Evaluation of treatment for sarcomas of the uterus.Cancer Clinical Trials, 2: 145–150, 1979.
12.
KademianM.T., BuchlerD.A., WirtanenG.W.: Bipedal lymphangiography in malignancies of the uterine corpus.A.J.R., 129: 903–906, 1977.
KrumholzB.A., LobouskyF.Y., HalitskyV.: Endolymphatic stromal myosis with pulmonary metastases.Remission with progestin therapy. Report of a case. J. Reprod. Med., 10: 85–89, 1973.
17.
LangleyF.A.: Malignant tumours of the uterine mesenchyme.Clin. Obstet. Gynecol., 3: 425–457, 1976.
18.
LehrnerL.M., MilesP.A., EnckR.E.: Complete remission of widely metastatic endometrial stromal sarcoma following combination chemotherapy.Cancer, 43: 1189–1194, 1979.
19.
MontagueA.C.W., SwartzD.P., WoodruffJ.D.: Sarcoma arising in a leiomyoma of the uterus.Am. J. Obstet. Gynecol., 92: 421–427, 1965.
20.
NorrisH.J., TaylorH.B.: Postirradiation sarcomas of the uterus.Obstet. Gynecol., 26: 689–694, 1965.
21.
OberW.B., TovellH.M.: Mesenchymal sarcomas of the uterus.Am. J. Obstet. Gynecol., 77: 246–268, 1959.
SchwartzD., FlamantR., LellouchJ.: L'essai therapeutique chez l'homme.Flammarion, Paris, 1970.
26.
SmithJ.P., RutledgeF., DelclosL., SutowW.: Combined irradiation and chemotherapy for sarcomas of the pelvis in females.Surg. Gynecol. Obstet., 123: 571–576, 1975.
27.
VongtamaV., KarlenJ.R., PiverS.M., TsukadaY., MooreR.H.: Treatment, results and prognostic factors in stage I and II sarcomas of the corpus uteri.A.J.R., 126: 139–147, 1976.
28.
WilliamsonE.O., ChristophersonW.M.: Mixed mullerian tumors of the uterus.Cancer, 29: 585–592, 1972.
29.
YazigiR., PiverS.M., BarlowJ.J.: Stage III uterine sarcoma: case report and literature review.Gynecol. Oncol., 8: 92–96, 1979.
