The effect of administration of Doxorubicin (Dx) on the bone marrow CFUs, CFUe and CFUe has been evaluated in mice following injection of scalar single doses of the drug or during its repeated (3 times in 5 days) or prolonged (5 or 10 weeks) administration. In the first experiment the dose survival curves were exponential and the sensitivity of the 3 types of hemopoietic progenitors assayed was almost similar. During repeated or prolonged administration of Doxorubicin the CFUs appeared to be less affected by the drug than the committed progenitors.
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References
1.
AlbertsD.S.Van Daalen Wetters: T.Rubidazone vs. Adriamycin: an evaluation of their differential toxicity in the spleen colony assay system. Br. J. Cancer, 34: 64–68, 1976.
2.
ArcamoneF., Di MarcoA., CasazzaA.M.: Chemistry and pharmacology of new antitumor anthracyclines. In: Advances in cancer chemiotherapy.UmerawaH. (Eds.), pp. 297–312, Japan Sci. Soc. Press. Tokyo Univ. Park Press.Baltimore, 1978.
3.
BlackettN.M., MarshJ.C., GordonM.Y., OkellS.F., AguadoH.: Simultaneous assay by six methods of the effect on hemopoietic precursor cells of Adriamycin, Methyl CCNU, 60CO Ray, Vinblastine and Cytosine-arabinoside.Exp. Hematol., 6: 2–8, 1978.
4.
BotnickL.E., HannonE.C., HellmanS.: Multisystem stem cell failure after apparent recovery from alkylating agents.Cancer Res., 38: 1942–1947, 1978.
5.
BradleyT.R., MetcalfD.: The growth of mouse bone marrow cells in vitro.Aust. J. Exp. Biol. Med. Sci., 44: 287–300, 1966.
BuickR.N., MessnerH.A., TillJ.E., McCullochE.A.: Cytotoxicity of adriamycin and daunorubicin for normal and leukemia progenitor cells of man.J. Natl. Cancer Inst., 62: 2, 249–255, 1979.
8.
CalabresiD., ParksR.E.J.: Chemioterapy of neoplastic diseases. In: GoodmanL.S., and GilmanA.: The pharmacological basis of terapeutics. pp. 1290–1292. 15th ed. McMillan publishing Co., New York1975.
9.
CasazzaA.M., Di MarcoA., BonadonnaG., BonfanteV., BertazzoliC., BelliniO., PratesiG., SalaL., BalleriniL.: Effects of modifications in position 4 of the chromophore or in position 4 of the aminosugar on the antitumor activity and toxicity of daunorubicin and doxorubicin. In: Anthracyclines.CrookeS.T., and ReichS.D. eds., Academic PressNew York1980.
10.
CasazzaA.M.: Preclinical studies for the evaluation of new anthracyclines analogs.Chemioter. Oncol., 4: 310–326, 1978.
11.
HryniukW.M., BertinoJ.R.: Rationale for the selection of chemiotherapeutic agents.Adv. Intern. Med., 15: 267–297, 1969.
12.
HuybrechtsM., SymannM., TrovetA.: Effects of daunorubicin and doxorubicin, free and associated with DNA, on hemopoietic stem cells.Cancer Res., 39: 3738–3743, 1979.
13.
IscoveN.N., SieberF., WinterhalterK.H.: Erythroid colony formation in cultures of mouse and human bone marrow: analysis of the requirement for erythropoietin by gel filtration and affinity chromatography on Agarose-concanavaline-a.J. Cell. Physiol., 83: 305–320, 1973.
14.
LajthaL.G.: Hemopoietic stem cells.Br. J. Hematol., 29: 529–535, 1975.
15.
MarshJ.C.: Comparision of the sensitivities of human, canine, and murine hematopoietic precursor cells to adriamycin and N-trifluoroacetyl-adriamycin-14-valerate.Cancer Res., 36: 360–364, 1979.
16.
MarshJ.C.: The effects of cancer chemioterapeutic agents on normal hemopoietic precursor cells: a review.Cancer Res., 36: 1853–1882, 1976.
17.
MassaG., BoglioloG., SavianeA., PannacciulliI.: Experimental study on bone marrow CFU, following anticancer drug administration to plethoric mice.Tumori, 65: 539–545, 1979.
18.
MetcalfD.: Effect of thimidine suiciding on colony formation in vitro by mouse hematopoietic cells.Proc. Soc. Exp. Biol. Med., 139: 511–514, 1972.
19.
PannacciulliI., MassaG., SavianeA., BianchiG., BoglioloG., GhioR.: The effects of chronic administration of ciclophosphamide on hemopoietic stem cells.Scand. J. Haematol., 19: 217–221, 1977.
20.
RazekA., ValerioteF., ViettiT.: Survival of hemopoietic and leukemic colony forming cells in vivo following adminstration of daunorubicin or adriamycin.Cancer Res., 32: 1496–1500, 1972.
21.
TillJ., McCullochE.A.: A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.Radiat. Res., 14: 213–222, 1961.
22.
VoglerW.R., MingioliE.S., GarwoodF.: The effects of methotrexate on granulocytic stem cells and granulopoiesis.Cancer Res., 33: 1628–1633, 1973.
