The case reported involves a young woman with a medullary thyroid carcinoma. Only during autopsy was it possible to show a pheochromocytoma of the left adrenal gland; multiple foci of atypical proliferation were observed, only microscopically, also in the adrenal gland. The authors emphasize the difficulty of a correct diagnosis during life and outline the necessity of an accurate screening of family members of a patient with Sipple's syndrome.
BlockM.B., RobertsP.J., KadairR.G., SeyferA.E., HullS.F., NofeldtF.D.: Multiple endocrine adenomatose type II B. JAMA, 234: 710–714, 1975.
3.
CasulaG., AngioyG., SiriguP., SiriguF.: Carcinoma of the thyroid gland, adenoma of the adrenal cortex and peptic ulcer: An unreported association. Tumori, 62: 665–672, 1976.
DonahoverG.F., SchumacherO.P., HazardJ.B.: Medullary carcinoma of the thyroid. A cause of Cushing's syndrome: Report of two cases. J. Clin. Endocrinol. Metab., 28: 1199–1204, 1968.
6.
EberleF., AdlerG., KernH.F., MartiniG.A.: Polypoid gastric heterotopy of the small intestine in a patient with primary hyperparathyroidism and alpha-I-antitrypsin deficiency belonging to a MEA-family. With particular reference to the ultrastructure of the epithelial cells. Z. Gastroenterol., 6: 354–365, 1979.
7.
EisenbergA.A., WallersteinH.: Pheochromocytoma of suprarenal medulla (paraganglioma). A clinicopathological study. Arch. Path., 14: 818–836, 1932.
8.
HazardJ.B., HawkW.A., CrileG.Jr.: Medullary (solid) carcinoma of the thyroid: Clinicopathological entity. J. Clin. Endocrinol., 19: 152–161, 1959.
9.
LipsC.J.M., MinderW.H., LeoJ.R., AllemanA., HackengW.H.L.: Evidence of multicentric origin of the multiple endocrine neoplasia syndrome type II A (Sipple's syndrome) in a large family in the Nederlands. Am. J. Med., 64: 569–578, 1978.
10.
PearseA.G.E.: The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic, and pathologic implications of the concept. J. Histochem. Cytochem., 17: 303–313, 1969.
11.
SchimkeR.N., HartmannW.H., ProutT.E., RimoinD.L.: Syndrome of bilateral pheochromocytoma, medullary thyroid carcinoma and multiple neuromas. New Engl. J. Med., 279: 1–7, 1968.
12.
SippleJ.H.: The association of pheochromocytoma with carcinoma of the thyroid gland. Am. J. Med., 31: 163–166, 1961.
13.
WilliamsE.D.: A review of 17 cases of carcinoma of the thyroid and pheochromocytoma. J. Clin. Pathol., 18: 288–292, 1965.
