Numerous epidemiologic, morphologic and experimental studies have demonstrated the precancerous significance of intestinal metaplasia. We report here the results of a histochemical study of intestinal metaplasia in which 2 types were observed: one with sialomucin-secreting cells typical of the small intestine, and the other with sulphomucin-secreting cells typical of colonic mucosa. The correlation between colonic type intestinal metaplasia and gastric cancer is explored, since a significant precancerous value for this type of intestinal metaplasia is suggested.
Get full access to this article
View all access options for this article.
References
1.
BordiC., RavazzolaM.: Endocrine cells in the intestinal metaplasia of gastric mucosa. Am. J. Pathol., 96: 391–398, 1979.
2.
CorreaP., CuelloC., DuqueE.: Carcinoma and intestinal metaplasia of the stomach in Colombian migrants. J. Natl. Cancer Inst., 44: 297–306, 1970.
3.
CorreaP., CuelloC., DuqueE., BurbanoL., GarciaF.T., BolomasO., BrownC., HaenszelW.: Gastric cancer in Colombia. III. Natural history of precursors lesions. J. Natl. Cancer Inst., 57: 1027–1035, 1976.
4.
CuelloC., CorreaP.: Dysplastic changes in intestinal metaplasia of the gastric mucosa. In: Gastric Cancer, pp. 83–90, HerfarthCh., SchangP. (eds.), Springer Verlag Berlin, Heidelberg, New York, 1979.
5.
FilipeM.I., BranfootA.C.: Abnormal patterns of mucus secretion in apparently normal mucosa of large intestine with carcinoma. Cancer, 34: 282–290, 1974.
6.
FilipeM.I., BranfootA.C.: Mucin histochemistry of the colon. In: Current Topics in Pathology, vol. 63, pp. 143–178, GrundmannE., and KristenW.H. (eds.), Springer Verlag, Berlin, Heidelberg, 1976.
7.
GadA.: A histochemical study of human alimentary tract mucosubstances in health and disease. I. Normal and tumours. Br. J. Cancer, 22: 52–63, 1969.
8.
GlassG.B.J., PitchumoniC.S.: Atrophic gastritis. Structural and ultrastructural alteration, exfoliative cytology and enzyme cytochemistry and histochemistry, proliferation kinetics, immunological derangements and other causes, and clinical association and sequellae. Hum. Pathol., 6: 219–250, 1975.
9.
GoldmanH., MingS.C.: Mucins in normal and neoplastic gastrointestinal epithelium. Arch. Pathol., 85: 580–586, 1968a.
10.
GoldmanH., MingS.C.: Fine structure of intestinal metaplasia and adenocarcinoma of the human stomach. Lab. Invest., 18: 203–210, 1968b.
11.
JassJ.R., FilipeM.I.: A variant of intestinal metapasia associated with gastric carcinoma: A histochemical study. Histopathology, 3: 191–199, 1979.
12.
KawachiT., KurisuM., SasjimaK., SanoT., SugimuraT.: Precancerous changes in the stomach. Cancer Res., 36: 2673–2677, 1976.
13.
KornE.R.: Intestinal metaplasia of the gastric mucosa. Endoscopic recognition and review of the literature. Am. J. Gastroenterol., 61: 270–275, 1973.
14.
LevR., SpicerS.S.: Specific staining of sulphate groups with Alcian blue at low pH. J. Histochem. Cytochem., 12: 309–314, 1964.
15.
LevR.: The mucin histochemistry of normal and neoplastic gastric mucosa. Lab. Invest., 14: 2080–2100, 1965.
16.
LevR., SiegelH., GlassG.B.J.: The enzymes histochemistry of gastric carcinoma in man. Cancer, 23: 1036–1093, 1969.
17.
MarcheC., GanterP.: Caract×res histochimique des mucines épithéliales dans la metaplasie intestinale de l'estomac. Ann. Anat. Pathol. (Paris), 17: 379–388, 1972.
18.
MatsukuraN., KawachiT., SasajimaK., SanoT., SugimuraT., HirotaT.: Induction of intestinal metaplasia in the stomachs of rats by N-methyl-N-nitro-N-nitrosoguanidine. J. Natl. Cancer Inst., 61: 141–144, 1978.
19.
MingS.C.: Tumors of the Esophagus and Stomach. Atlas of Tumor Pathology, 1973, Armed Forces Institute of Pathology, Washington, D.C.
20.
MorsonB.C.: Carcinoma arising from area of intestinal metaplasia in the gastric mucosa. Br. J. Cancer, 9: 377–385, 1955b.
MunozN., MatkoL.: Histological types of gastric cancer and its relationship with intestinal metaplasia. Recent results Cancer Res., 39: 99–105, 1972.
23.
NakaharaK.: Special features of intestinal metaplasia and its relation to early gastric carcinoma in man; observation by a method in which leucine aminopeptidase activity is used. J. Natl. Cancer Inst., 61: 693–702, 1978.
24.
SasanoN., NokamuraK., AraiM., AkazakiK.: Ultrastructural cell patterns in human gastric carcinoma compared with non neoplastic gastric mucosa. Histogenetic analysis of carcinoma by mucin histochemistry. J. Natl. Cancer Inst., 43: 783–802, 1969.
25.
SpicerS.S., MeyerD.B.: Histochemical differentiation of acid mucopolysaccharides by means of combined aldehyde fuchsin-Alcian blue staining. Am. J. Clin. Pathol., 33: 453–460, 1960.
26.
StemmermannG.N., HayashiT.: Intestinal metaplasia of the gastric mucosa: A gross and mricroscopic study of its distribution in various disease states. J. Natl. Cancer Inst., 41: 627–634, 1968.
