Total and unsaturated folate binding capacity (TFBC-UFBC) was measured in 44 normal volunteers and in 77 patients with solid tumors; of them 31 had a lung cancer, 18 a cancer of the gastrointestinal tract (GI), and 28 a breast cancer. With the exception of patients with cancer of the stomach, all the other groups showed a significant increase in TFBC. An increase in UFBC was statistically observed in patients with lung cancer and cancer of the GI tract. No correlation was observed in breast cancer between the presence of hormon receptors on cancer tissue and the value of TFBC. However, a significant increase in TFBC was noted in this group of patients when metastases were present.
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References
1.
ChesterE., FehertyP., KellieA.E., RalphsD.N.C.: Estrogen receptors in primary breast tumors in relation the stage and progression of the disease. In: Estrogen Receptors in Human Breast Cancer. p. 157, McGuireW.L., RaynaudJ.P., BaulieyE.E. (eds.), Raven Press, New York, 1975.
2.
ColmanN., HerbertV.: Total folate binding capacity of normal human plasma and variation in uremia, cirrhosis and pregnancy. Blood, 48: 911–921, 1976.
3.
CorrocherR., De SandreG., PachorM.L., HoffbrandA.V.: Hepatic proteins binding of folate. Clin. Sci. Mol. Med., 46: 551–554, 1974.
4.
CorrocherR., De SandreG., AmbrosettiA., PachorM.L., BambaraL.M., HoffbrandA.V.: Specific and non-specific folate binding proteins in normal and malignant tissues. J. Clin. Pathol., 31: 659–665, 1978.
5.
CorrocherR., PachorM.L., BambaraL.M., BiasiN., StanziaiA., De SandreG.: Serum folate binding capacity in leukaemias, liver diseases and pregnancy. Acta Haemat., 61: 203–208, 1979.
6.
CorrocherR., BambaraL.M., PachorM.L., StanziaiA.M., LunardiC., De SandreG.: Breast cancer and serum folate binding capacity. Eur. J. Cancer, 16: 1233–1236, 1980.
7.
Da CostaM., RothenbergS.P., KamenB.: DNA synthesis in chronic myelogenous leukemia cells: Comparison of results in cell containing folate binding factor to replicating cells without binder. Blood, 39: 621–627, 1972.
8.
Da CostaM., RothenbergS.P.: Appearance of folate binder in leukocytes and serum of women who are pregnant or taking oral contraceptives. J. Lab. Clin. Med., 83: 207–214, 1974.
9.
Da CostaM., RothenbergS.P., CohenJ.: Folate binding protein in serum from smokers and patients with lung cancer and in extracts of lung tissue. Clin. Res.: 26, 534, 1978.
10.
RothenbergS.P., Da CostaM.: Folate binding proteins and radioassay for folate. Clin. Haematol., 6: 569–587, 1976.
11.
RothenbergS.P., FischerC.D., Da CostaM.: Binding of N5, N10-methylentetrahydrofolate and the inhibition of thymidylate synthesis by a folate binding protein. Biochim. Biophys. Acta, 543: 340–348, 1978.
12.
WaxmanS., ScaulonK.J., SchreiberC.: Folate binding protein acts as a non competitive inhibitor for dihydrofolate reductase. Proc. XVIII Congr. Intern. Soc. Haematol., Abstr. 1593, Montreal, 1980.
