A case of hepatocellular carcinoma with intracytoplasmic hyaline globules is reported. By serological, histochemical, immunofluorescent and electron microscopic studies the authors maintain that in this case intracytoplasmic hyaline globules represent lysosomal structures. According to Von Ardenne's theory, these lysosomal globules appear related to neoplastic cells necrosis.
Get full access to this article
View all access options for this article.
References
1.
AllenR.C., HarleyR.A., TalamoR.: A new method for determination of alpha–1-antitrypsin phenotypes using isoelectric focusing on Polyacrylamide gel slabs.Am. J. Clin. Pathol.,62: 732–739, 1974.
2.
AndersonP.J., CohenS., BarkaT.: Hepatic injury. A histochemical study of intracytoplasmic globules occurring in liver injury.Arch. Pathol.,71: 101–107, 1961.
3.
Von ArdenneM.: Die selektive einer primaren Krebs-zellenschädigung als Fundamental-prozess der Krebs-Mehrschritt-Therapie. Turin lecture. In: Il Cancro. pp. 268–269. SussR., KinzelV., ScribnerJ.D. (eds.). Edizione italiana di G.M. Pontieri, Piccin Editore, Padova, 1977.
4.
BellO.F., CarrelR.W.: Basis on the defect in α1-antitrypsin deficiency.Nature,243: 410–411, 1973.
5.
BergN.O., ErikssonS.: Liver disease in adults with α1-antitrypsin deficiency.N. Engl. J. Med.,287: 1264–1267, 1972.
6.
BrandB., BezahlerG.H., GouldR.: Cirrhosis and heterozygous FZ α1-antitrypsin deficiency in an adult.Gastroenterology,66: 264–268, 1974.
7.
CampraJ.L., CraigJ.R., PetersR.L., ReynoldsT.B.: Cirrhosis associated with partial deficiency of α1-antitrypsin in an adult.Ann. Intern. Med.,78: 233–238, 1973.
8.
ChuM.L., LinW., YoshidaT.O., ChuS., LinT.: Demonstration of α-fetoglobulin in hepatoma tissue by fluorescent antibody technique.Cancer,34: 268–273, 1974.
9.
CohenC.: Intracytoplasmic hyaline globules in hepatocellular carcinomas.Cancer,37: 1754–1758, 1976.
ErikssonS., HagerstrandI.: Cirrhosis and malignant hepatoma in α1-antitrypsin deficiency.Acta Med. Scand.,195: 451–458, 1974.
16.
ErikssonS., LarssonC.: Purification and partial characterization of PAS-positive inclusion bodies from the liver in α1-antitrypsin deficiency.N. Engl. J. Med.,23: 176–180, 1975.
17.
FagerholM.K., LaurellC.B.: The PI System-inherited variants of serum α1-anti-trypsin.Prog. Med. Genet.,7: 96–111, 1970.
18.
FeldmannG., BignonJ., ChahinianP.: The liver in ai-antitrypsin deficiency.Digestion,10: 162–174, 1974.
19.
GanrotP.O., LaurellC.B., ErikssonS.: Obstructive lung disease and trypsin inhibitors in α1-antitrypsin deficiency.Scand. J. Lab. Clin. Invest.,19: 205–208, 1967.
20.
GubettaL., RizzettoM., VermeG.: A trichrome stain for the detection of hepatitis B surface antigen in liver biopsies.Pathologica,68: 413–416, 1976.
HartM.N., CyrusA.: Hyaline globules of the adrenal medulla.Am. J. Clin. Pathol.,49: 387–391, 1968.
23.
IshakK.G., GlunzP.R.: Hepatoblastoma and hepatocarcinoma in infancy and childhood. Report of 47 cases.Cancer,20: 396–422, 1967.
24.
ItohT., ShiraiI., NakaA., MatsumotoS.: Yolk sac tumor and α1-fetoprotein. Clinico-pathological study of 4 cases.Gann,65: 215–226, 1974.
25.
KeeleyA.F., IseriO.A., GottliebL.S.: Ultrastructure of hyaline cytoplasmic inclusions in a human hepatoma. Relationship to Mallory's alcoholic hyaline.Gastroenterology,62: 280–293, 1972.
26.
KerrI.F.R.: An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine.Pathology,1: 83–94, 1969.
27.
KueppersF., BlackL.F.: Alpha1-antitrypsin and its deficiency.Am. Rev. Resp. Dis.,110: 176–194, 1974.
SmithJ.A., FrancisT.I., EdingtonG.M., WilliamsA.O.: Immunofluorescent localization of human α-fetoprotein in fetal and neonatal livers and cultured cells from hepatocellular carcinoma.Br. J. Cancer,25: 343–349, 1971.
39.
SmetanaK., GyorkeyF., GyorkeyP., BuschH.: Studies on nucleoli and cytoplasmic fibrillar bodies of human hepatocellular carcinomas.Cancer Res.,32: 925–932, 1972.
40.
TeilumG.: Classification of endodermal sinus tumor (mesoblastoma vitellinum) and so-called embryonal carcinoma of the ovary.Acta Pathol. Microbiol. Scand.,64: 407–429, 1965.
41.
TeilumG., AlbrechtsenR., Norgaard-PedersonB.: Immunofluorescent localization of α-fetoprotein synthesis in endodermal sinus tumor (yolk sac tumor).Acta Pathol. Microbiol. Scand.,82A: 586–588, 1974.
42.
TothK., SomosyZ., BenceJ., SugarJ.: Study of globular bodies found in hepatomas of Swiss mices.Z. Krebsforsch,84: 67–73, 1975.
43.
VogelC.L., PrimackA., McIntireK.R., CarboneP.P., AnthonyP.O.: Serum α-fetoprotein in 184 Ugandan patients with hepatocellular carcinoma. Clinical laboratory and histopathological correlations.Cancer,33: 959–964, 1974.
44.
WilkinsonE.J., RaabK., BrowningC.A., HostyT.A.: Familial hepatic cirrhosis in infants associated with α1-antitrypsin SZ phenotypes.J. Pediatr.,85: 159–162, 1974.
45.
YunisE.J., AgostiniR.M., GlewR.H.: Fine structural observation of the liver α1-antitrypsin deficiency.Am. J. Pathol.,82: 265–286, 1976.
