Correlation between Clinical Response to Bilateral Oophorectomy,Estrogen Receptors and Urinary Androgen Excretion in 49 Patients with Advanced Breast Cancer
Restricted accessResearch articleFirst published online June, 1979
Correlation between Clinical Response to Bilateral Oophorectomy,Estrogen Receptors and Urinary Androgen Excretion in 49 Patients with Advanced Breast Cancer
The aim of this study was to find out if it is possible to predict the clinical response to bilateral oophorectomy in premenopausal patients with advanced breast cancer. Two methods of determination were used before oophorectomy: 1) the presence of estrogen receptors in the tumor tissue; 2) the urinary concentration of androgens. The clinical response to oophorectomy was evaluated after a six-month follow-up. Determinations carried out on 49 patients showed that a significant correlation exists between clinical response to oophorectomy and androgenic activity alone or in combination with estrogen receptors when both tests give concordant results.
Get full access to this article
View all access options for this article.
References
1.
Di FronzoG., BertuzziA., RonchiE.: An improved criterion for the evaluation of estrogen receptors binding data in human breast cancer.Tumori, 64: 259–266, 1978.
2.
EORTC Breast Cancer Cooperative Group:Standards for the assessment of oestrogen receptors in human breast cancer.Eur. J. Cancer,9: 379–381, 1973.
3.
GrattarolaR.: Ovariectomy alone or in combination with dexamethasone in patients with advanced breast cancer and high levels of testosterone excretion.J. Natl. Cancer Inst., 56: 11–15, 1976.
4.
GrattarolaR.: Androgens in breast cancer. I. Atypical endometrial hyperplasia and breast cancer in married premenopausal women.Am. J. Obstet. Gynecol., 116: 423–428, 1973.
5.
JensenE.V., BlockG.F., SmithS., DesombreE.R.: Hormonal dependency of breast cancer.In: Recent Results in Cancer Research. Breast Cancer: A challenging problem, pp. 55–62. Springer-Verlag, Berlin-New York, 1973.
6.
Mauvais-JervisP., CharrausalG., Babas-MassonF.: Simultaneous determination of urinary androstanediol and testosterone as an evaluation of human androgenicity.J. Clin. Endocrinol. Metab., 36: 452–459, 1973.
7.
McGuireW.L., CarboneP.P., SearsM.E., EsherG.C.: Estrogen receptors in human breast cancer.An Overview.McGuireW.L., CarboneP.P., VollmerE.P. (eds.). In: Estrogen Receptors in Human Breast Cancer, pp. 1–8. New York, Raven Press, 1975.
8.
VeronesiU., PizzocaroG., RossiA.: Oophorectomy for advanced carcinoma of the breast.Surg. Gynecol. Obstet., 141: 569–570, 1975.
