Increased localization (trapping) of lymphocytes occurs in lymphoid organs following antigenic challenge. The effect of peptichemio (PTC) upon lymphocyte trapping in lymph nodes and spleen was investigated: the results demonstrate that the drug diminishes trapping in lymphatic organs. The depression of lymphocyte trapping may provide at least one mechanism whereby PTC achieves its immunosuppressive effects.
Get full access to this article
View all access options for this article.
References
1.
AshersonG. L.BarnesR. M. R.: Contact sensitivity in the mouse. IX. The role of immunological and non-immunological inflammation in the movement of lymphocytes to immunized lymph nodes.Immunology, 24: 885–894, 1973.
2.
BoyleW.: An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.Transplantation, 6: 761–764, 1968.
3.
CahillR. N. P.FrostH.TrnkaZ.: The effects of antigen on the migration of recirculating lymphocytes through single lymph nodes.J. Exp. Med., 143: 870–888, 1976.
CarusoC.AmmatunaP.CariniC.SalernoA.: Induzione di interferon ed ipersensibilità ritardata.Atti Accad. Science Mod., Palermo, 1977 (in press).
6.
CarusoC.BellaviaA.CillariE.AscoliR.Pavone-MacalusoM.: Effects of high doses of peptichemio upon the humoral response to sheep erythrocytes and delayed hypersensitivity reactions to oxazolone in CBA mice.Tumori, 63: 147–154, 1977.
7.
De BarbieriA.: Fondamenti biologico-molecolari di un farmaco antineo-plastico: il peptichemio. pp. 175–196. In: Progressa in Chemioterapia Antitumorale.Casa Editrice Ambrosiana, Milano, 1976.
8.
DresserD. F.TaubR. N.KrantzA. R.: The effect of localized injection of adjuvant material on the draining lymph node.II. Circulating lymphocytes. Immunology, 18: 663–670, 1970.
9.
FordW. L.: The recruitment of recirculating lymphocytes in the antigenically stimulated spleen. Specific and non-specific consequences of initiating a secondary antibody response.Clin. Exp. Immun., 12: 243–254, 1972.
10.
FrostP.LanceE. M.: The cellular origin of the lymphocyte trap.Immunology, 26: 175–186, 1974.
11.
GoldschneiderI.McGregorD. D.: Migration of lymphocytes and thymocytes in the rat. I. The route of migration from blood to spleen and lymph nodes.J. Exp. Med., 127: 155–168, 1968.
12.
HayJ. B.HobbsB. B.: The flow of blood to lymph nodes and its relation to lymphocyte traffic and the immune response.J. Exp. Med., 145: 31–44, 1977.
13.
InchleyC. J.MicklemH. S.BarretJ.HunterJ.MintyC.: Age-related changes in localization of injected radiolabelled lymphocytes in the lymph nodes of antigen-stimulated mice.Clin. Exp. Immun., 26: 286–294, 1976.
14.
KaranovicD.MajL.KaranovicJ.AstaldiG.: Effetto del peptichemio sulla blastogenesi dei linfociti del sangue periferico del ratto. Bull. 1st.Sieroter. Mil., 53: 351–354, 1974.
15.
MonginiP. K. A.RosenbergL. T.: Inhibition of lymphocyte trapping by cell-free ascitic fluids cultivated in syngeneic mice.J. Immun., 114: 650–654, 1975.
16.
MonginiP. K. A.RosenbergL. T.: Inhibition of lymphocyte trapping by a passenger virus in murine ascitic tumors: characterization of lactic dehydrogenase virus (LDV) as the inhibitory component and analysis of the mechanism of inhibition.J. Exp. Med., 143: 100–113, 1976.
17.
PribnowJ. F.SilvermanM. S.: Studies on the radiosensitive phase of the primary antibody response in rabbits. I. The role of the macrophage.J. Immun., 98: 225–229, 1967.
18.
RowleyD. A.GowansJ. L.AtkinsR. C.FordW. L.SmithM. E.: The specific selection of recirculating lymphocytes by antigen in normal and preimmunized rats.J. Exp. Med., 136: 499–513, 1972.
19.
SprentJ.MillerJ. F. A. P.MitchellG. F.: Antigen-induced selective recruitment of circulating lymphocytes.Cell. Immun., 2: 171–182, 1971.
20.
TaubR. N.KrantzA. R.DresserD. W.: The effect of localized injection of adjuvant material on the draining lymph node.I. Histology. Immunology, 18: 171–186, 1970.
21.
ZatzM. M.: Lymphocyte trapping. Differential effects of ATS and irradiation on trapping in lymph nodes and spleen.Immunology, 30: 749–753, 1976.
22.
ZatzM. M.: Effects of BCG on lymphocyte trapping.J. Immun., 116: 1587–1591, 1976.
