The presence of oncornavirus particles in BALB/c mouse cells transformed by adenovirus 7 was investigated. The particles detected had a buoyant density of 1.16 g/cm3; both p30 and adenovirus T-specific immunofluorescence was demonstrated in the cell cytoplasm. No C-particles were shown by the electron microscope.
Get full access to this article
View all access options for this article.
References
1.
AokiT., TodaroG. J.: Antigenic properties of endogenous type-C virus from spontaneously transformed clones of BALB/3T3. Proc. Nat. Acad. Sci. USA, 70: 1598–1602, 1973.
2.
LowyD. R., RoweW. P., TeichN., HartleyJ. W.: Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science, 174: 155–156, 1971.
3.
PauluzziS., RappF.: Antigenic and oncogenic properties of a cell line derived from a hamster brain tumor induced by simian adenovirus 7. J. Nat. Cancer Inst., 43: 1165–1173, 1969.
4.
PauluzziS., RibacchiR., FrongilloR., ZeppaM. P.: The histopathology of tumors induced by PARA-adenovirus 7 transformed cell clones. Europ. J. Cancer, 6: 537–543, 1970.
5.
RappF., ConnerR., GlaserR., DuffR.: Absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2. J. Virol.9: 1059–1063, 1972.
6.
SalomonJ. C.: Aspects ultrastructuraux des tumeurs de souris induites par l'adenovirus 12. Int. J. Cancer, 2: 225–230, 1967.
7.
StenbackW. A., Van HoosierG. L.Jr., TrentinJ. J.: Virus particles in hamster tumors as revealed by electron microscopy. Proc. Soc. Exp. Biol. Med., 122: 1219–1223, 1966.
8.
TodaroG. J.: Spontaneous release of type-C virus from clonal lines of « spontaneously » transformed BALB/3T3 cells. Nature New Biol., 240: 157–160, 1972.
9.
TodaroG. J., HuebnerR. J.: The viral oncogene hypothesis: new evidence. Proc. Nat. Acad. Sci. USA, 69: 1009–1015, 1972.
