Six intracarotid artery infusions of DTIC were performed in 4 patients with invasive malignant melanoma of the maxillo-facial region. A total dose of 3.5 to 7 g was well tolerated. Only 1 patient who received 9.5 g in 25 days developed a reversible bone marrow depletion. Two out of the 4 patients presented a transient 50 % tumor surface regression, but no response was seen after the second infusion. Of the 2 remaining patients, 1 had no measurable effect and 1 experienced tumor progression.
De WaschG., BernheimJ., MichelJ., LejeuneF., KenisY.: Combination chemotherapy with 3 marginally effective agents, CCNU, vincristine, and bleomycin, in the treatment of stage III melanoma. Cancer Treat. Rep., 60: 1273–1276, 1976.
3.
JortayA.: Essai séquentiel sur la chimiothérapie intra-artérielle dans les épithéliomas invasifs de la cavité buccale. Bull. Cancer, 1975 (in press).
