Several organs of newborn or adult C57BL/He and C57BL/6J mice and of infant AKR mice were examined for type-C viral particles after treatment with dexamethasone, a corticosteroid hormone that stimulates C virus replication. In both C57BL strains C particles were consistently found in the exocrine pancreas of the newborns but in smaller number than that previously observed in the adults. No C particles were observed in the submaxillary salivary glands, bones or other organs examined in adult C57BL/He and C57BL/6J mice. In infant AKR mice, few C particles were observed in the exocrine pancreas or submaxillary salivary glands whereas they were found to be produced in large number by bone cells. The results suggest that in C57BL/He and C57BL/6J mice endogenous C particle production is continuous throughout life in the exocrine pancreas and is restricted to this tissue.
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References
1.
AbelevG.I., ElgortD. A.: Group-specific antigen of murine leukemia viruses in mice of low-leukemic strains. Int. J. Cancer, 6: 145–152, 1970.
2.
BoiocchiM., Della TorreG., Della PortaG.: Genetic control of endogenous C-type virus production in pancreatic acinar cells of C57BL/He and C57BL/6J mice. Proc. Nat. Acad. Sci., 72: 1892–1894, 1975.
CheungK.-S., SmithR. E., StoneM. P., JoklikW. K.: Comparison of immature (rapid harvest) and mature Rous sarcoma virus-particles. Virology, 50: 851–864, 1972.
5.
Della TorreG., Della PortaG.: Type C viruses in the pancreas of normal C57BL mice. Cancer Res., 32: 1595–1597, 1972.
6.
DoellR. G., CarnesW. M.: Urethan induction of thymic lymphoma in C57BL mice. Nature, 194: 588–589, 1962.
7.
DoughertyR. M., Di StefanoH. S.: Sites of avian leukosis virus multiplication in congenitally infected chickens. Cancer Res., 27: 322–332, 1967.
8.
DuplanJ. F.: Recherches sur l'action leucémogène des extraits de tissus de souris C57BL. Bull. Cancer, 52: 117–125, 1965.
9.
EastJ., ProsserP. R., HolborowE. J., JaquetH.: Autoimmune reactions and virus-like particles in germ-free NZB mice. Lancet, 1: 755–757, 1967.
10.
FeldmanD. G., GrossL.: Electron microscopic study of the distribution of the mouse leukemia virus (Gross) in organs of mice and rats with virus-induced leukemia. Cancer Res., 26: 412–426, 1966.
11.
HallW. T., GazdarA. F., HobbsB. A., ChopraH. C.: Morphology of a « non-infectious » sarcoma virus. J. Nat. Cancer Inst., 52: 1337–1343, 1974.
12.
Haran-GheraN.: A leukemogenic filtrable agent from chemically-induced lymphoid leukemia in C57BL mice. Proc. Soc. Exp. Biol. Med., 124: 697–699, 1967.
13.
HarrisonA. K., MurphyF. A.: Murine oncornavirus activation in the pancreas during infection with Venezuelan equine encephalitis virus. J. Nat. Cancer Inst., 55: 917–923, 1975.
14.
HeineV., De TheG., BeardD., BeardJ. W.: Multiplicity of cell response to the BAI-strain A (myeloblastosis) avian tumor virus. V. Elaboration of virus by pancreas of chickens inoculated with the agent. J. Nat. Cancer Inst., 30: 817–835, 1963.
15.
HilgersJ., DecleveA., GaleslootJ., KaplanH. S.: Murine leukemia virus group-specific antigen expression in AKR mice. Cancer Res., 34: 2553–2561, 1974.
16.
HollmannK. H., VerleyJ. M.: Présence de particules virales dans les organes de la souris NZB. C. R. Acad. Sci. Paris, 264: 871–873, 1967.
17.
HuebnerR. J., KelloffG. J., Sarmap. S., LaneW. T., TurnerH. G.: Group–specific antigen expression of the C-type RNA tumor virus genoma during embryo-genesis: Implications for ontogenesis and oncogenesis. Proc. Nat. Acad. Sci., 67: 366–376, 1970.
KaplanH. S.: On the natural history of the murine leukemias: Presidential Address. Cancer Res., 27: 1325–1340, 1967.
20.
LagerlofB.: The ultrastructure of virus- and radiation-induced thymomas of C57BL mice. Acta Path. Microbiol. Scand., 74: 495–513, 1968.
21.
ParanM., GalloR. C., RichardsonL. S., WUA.M.: Adrenal corticosteroide enhance production of type-C virus induced by 5-iodo-2′-deoxyuridine from cultured mouse fibroblasts. Proc. Nat. Acad. Sci., 70: 2391–2395, 1973.
22.
ParsonsD. F., UptonA. C., BenderM. A., JenkinsV. K., NelsonE. S., JohnsonR. R.: Electron microscopic observations on primary and serially passaged radiation-induced myeloid leukemias of the RF mouse. Cancer Res., 22: 728–736, 1962.
23.
Ricciardi-CastagnoliP., JadinJ. M., MaisinJ. R.: Electron microscopic study of lymphatic tissue of mice inoculated with a leukemogenic extract from radiation-induced tumors. Cancer Res., 33: 2476–2488, 1973.
24.
RoweW. P., PincusT.: Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice. J. Exp. Med., 135: 429–436, 1972.
25.
RudaliG., SilbermanC.: Apparition de leucémies chez des souris C57BL après greffe d'organs normaux isologues. Nouv. Rev. Fr. Hematol., 5: 63–68, 1965.
26.
SchofieldB. H., BarrettC. P., DotyS. B., FiggeF. H. J., RobinsonR. A.: Formation of virus-like particles by bone cells in mice with a high incidence of spontaneous leukemia. Science, 168: 588–589, 1970.
27.
VernonM. L., LoneW. T., HuebnerR.: Prevalence of type-C particles in visceral tissues of embryonic and newborn mice. J. Nat. Cancer Inst., 51: 1171–1175, 1973.
28.
WarshanskyH., MoreG.: A technique for the fixation and decalcification of rat incisors for electron microscopy. J. Histoch. Cytoch., 15: 542–549, 1967.
29.
YumotoT., DmochowskiL.: Light and electron microscope studies of organs and tissues of the New Zealand Black (NZB/BL) strain mice with lymphoid leukaemia and auto-immune disease. Cancer Res., 27: 2083–2097, 1967.
30.
ZeigelR. F.: Morphological evidence of the association of virus particles with the pancreatic acinar cells of the chick. J. Nat. Cancer Inst., 26: 1011–1039, 1961.
